
NCBI . NLM . NIH . GOV {
}
Title[redir]:
An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma - PMC
Description:
Dysregulated metabolism is a hallmark of cancer, manifested through alterations in metabolites. We performed metabolomic profiling on 138 matched clear cell renal cell carcinoma (ccRCC)/normal tissue pairs and found that ccRCC is characterized by ...
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Keywords {π}
metabolic, doi, figure, cancer, metabolites, ccrcc, tumors, metabolism, google, scholar, pubmed, data, pathway, pmc, cell, article, metabolomics, genes, stage, free, nature, tumor, kidney, expression, glutathione, normal, abundance, pathways, patients, tcga, analysis, levels, gene, progression, metabolite, increased, performed, profiling, cluster, clinical, samples, mcluster, table, differential, fold, tissues, cohort, research, significantly, cycle,
Topics {βοΈ}
joint tcga/high-glutathione dataset mann-whitney u-tests pmc beta search multi-omics approach reveals von hippel-lindau community-driven global reconstruction glycolysis diverts hexose-phosphates vitro cell-based assays rna-seq read counts targeting ros-buffering capacity tumor-induced gene expression explain substrate-induced flux web-based analytic tool fdr-corrected mann whitney fundamental tumor-initiating event late-stage/early-stage tumors keap1-null mutation leads produce cytosolic acetyl-coa kirc tcga rna-seq stage i-iii diseases protein degradation/reutilization processes vander heiden mg large-scale tumor metabolomics exhibiting statistically significant supplementary materials included cell-based assays demonstrated similar expression profiles integrative βmulti-omicsβ perspective metabolic pathway-based analysis published multi-omics datasets mitochondrion-defective tumor cells metabolic pathway-based integration including folate/methionine cycle fresh frozen analyzed rna-seq data stage iii/iv tumors adjacent normal tissue renal cell carcinoma nrf2-keap1 signaling pathway high/low stage samples kras-regulated metabolic pathway metabolic pathway-level data genome-wide scale footnotes publisher' tumor suppressor gene benjamini-hochberg corrected unsupervised clustering reveals reactive oxygen species benjamini-hochberg procedure cancer research community
Questions {β}
- Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
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- What's the income generated by https://scholar.google.com/scholar_lookup?journal=Nature&title=Metabolomic%20profiles%20delineate%20potential%20role%20for%20sarcosine%20in%20prostate%20cancer%20progression.&author=A%20Sreekumar&author=LM%20Poisson&author=TM%20Rajendiran&author=AP%20Khan&author=Q%20Cao&volume=457&publication_year=2009&pages=910-914&pmid=19212411&doi=10.1038/nature07762& each month?
- How much does https://scholar.google.com/scholar_lookup?journal=Nature&title=Comprehensive%20molecular%20characterization%20of%20clear%20cell%20renal%20cell%20carcinoma.&author=CJ%20Creighton&author=M%20Morgan&author=PH%20Gunaratne&author=DA%20Wheeler&author=RA%20Gibbs&publication_year=2013& rake in every month?
- https://doi.org/10.1038/nbt.2488's revenue stream
- https://scholar.google.com/scholar_lookup?journal=Nature%20biotechnology&title=A%20community-driven%20global%20reconstruction%20of%20human%20metabolism.&author=I%20Thiele&author=N%20Swainston&author=RM%20Fleming&author=A%20Hoppe&author=S%20Sahoo&volume=31&publication_year=2013&pages=419-425&pmid=23455439&doi=10.1038/nbt.2488&'s financial summary
- Check the income stats for https://doi.org/10.1038/nrd2803
- How much revenue does https://scholar.google.com/scholar_lookup?journal=Nature%20reviews%20Drug%20discovery&title=Targeting%20cancer%20cells%20by%20ROS-mediated%20mechanisms:%20a%20radical%20therapeutic%20approach?&author=D%20Trachootham&author=J%20Alexandre&author=P%20Huang&volume=8&publication_year=2009&pages=579-591&pmid=19478820&doi=10.1038/nrd2803& produce monthly?
- How much does https://doi.org/10.1126/science.1160809 pull in?
- How much money does https://scholar.google.com/scholar_lookup?journal=Science&title=Understanding%20the%20Warburg%20effect:%20the%20metabolic%20requirements%20of%20cell%20proliferation.&author=MG%20Vander%20Heiden&author=LC%20Cantley&author=CB%20Thompson&volume=324&publication_year=2009&pages=1029-1033&pmid=19460998&doi=10.1126/science.1160809& generate?
- Financial intake of https://doi.org/10.1038/ng1248
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- What's the monthly money flow for https://doi.org/10.1038/nrurol.2015.260?
- Profit of https://scholar.google.com/scholar_lookup?journal=Nature%20reviews%20Urology&title=A%20river%20model%20to%20map%20convergent%20cancer%20evolution%20and%20guide%20therapy%20in%20RCC.&author=EY%20Wei&author=JJ%20Hsieh&publication_year=2015&pmid=26526752&doi=10.1038/nrurol.2015.260&
- What's the income of https://doi.org/10.1073/pnas.1117773108?
- What's https://scholar.google.com/scholar_lookup?journal=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20of%20the%20United%20States%20of%20America&title=Hypoxia%20promotes%20isocitrate%20dehydrogenase-dependent%20carboxylation%20of%20alpha-ketoglutarate%20to%20citrate%20to%20support%20cell%20growth%20and%20viability.&author=DR%20Wise&author=PS%20Ward&author=JE%20Shay&author=JR%20Cross&author=JJ%20Gruber&volume=108&publication_year=2011&pages=19611-19616&pmid=22106302&doi=10.1073/pnas.1117773108&'s gross income?
- Discover the revenue of https://github.com/ncbi
- Earnings of https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323
- How much does https://www.nlm.nih.gov/web_policies.html gross monthly?
- What's the monthly income of https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office?
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- What's the financial gain of https://www.nlm.nih.gov/accessibility.html?
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- Find out how much https://www.nlm.nih.gov/ earns monthly
- How much income does https://www.nih.gov/ have?
- Learn how profitable https://www.hhs.gov/ is on a monthly basis
- How much money does https://www.usa.gov/ make?
Analytics and Tracking {π}
- Google Analytics
- Google Analytics 4
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Libraries {π}
- jQuery
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- Lazy.js
- Zoom.js
Emails and Hosting {βοΈ}
Mail Servers:
- nihcesxway.hub.nih.gov
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- nihcesxway4.hub.nih.gov
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Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
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CDN Services {π¦}
- Ncbi