
NCBI . NLM . NIH . GOV {
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Title[redir]:
Androgen Receptor Promotes Tamoxifen Agonist Activity by Activation of EGFR in ERα-Positive Breast Cancer - PMC
Description:
Tamoxifen (Tam) resistance represents a significant clinical problem in estrogen receptor (ER) -positive breast cancer. We previously showed that decreased expression of Rho guanine nucleotide dissociation inhibitor (Rho GDI), a negative regulator ...
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Keywords {🔍}
cells, egfr, cancer, tam, doi, rho, breast, expression, activation, zrb, activity, treatment, levels, resistance, mcf, erα, fig, google, scholar, pubmed, receptor, growth, signaling, phosphorylation, protein, tumors, therapy, increased, cell, analysis, gdi, enzalutamide, agonist, genes, erk, proliferation, gdiα, vec, estrogen, gene, endocrine, androgen, factor, control, total, pmc, res, data, ser, media,
Topics {✒️}
er/her2-positive breast cancer pmc beta search horseradish peroxidase-linked mouse basal p-p44/42 mapk 10549_2015_3609_moesm2_esm nihms732109-supplement-10549_2015_3609_moesm2_esm 10549_2015_3609_moesm3_esm nihms732109-supplement-10549_2015_3609_moesm3_esm 10549_2015_3609_moesm4_esm nihms732109-supplement-10549_2015_3609_moesm4_esm 10549_2015_3609_moesm5_esm nihms732109-supplement-10549_2015_3609_moesm5_esm 10549_2015_3609_moesm6_esm nihms732109-supplement-10549_2015_3609_moesm6_esm bi-directional cross-talk egfr/mapk/erk signaling pathway trans-lentiviral packaging system mitogen-activated protein kinase er-positive breast cancer robust multi-chip average ligand-dependent transcription factor altered post-translational modifications block tam-induced phosphorylation phenol-red-free media org/gsea/msigdb/collections tamoxifen-resistant breast cancer attenuated tam-induced proliferation estrogen receptor alpha pi3k/akt signaling routes ere-luciferase reporter assay anchorage-independent growth assays rabbit secondary antiobodies tam-induced erα activation p-p44/42 mapk steroid receptor regulation egfr/erk pathway members bidirectional cross talk supplementary materials included positive breast cancer tam-induced egfr activation human breast cancers shrna expression sequence progesterone receptor-positive steroid antagonist action prostate cancer cells human breast cancer estrogen-regulated genes cathepsin androgen receptor expression enhanced chemiluminescence reagent rho gdiα knockdown unliganded estrogen receptor progression-free survival [22] early breast cancer publisher site pdf transfected β-galactosidase
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