
NCBI . NLM . NIH . GOV {
}
Title[redir]:
MiR-497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG-1 - PMC
Description:
Hepatocellular carcinoma (HCC) is a worldwide malignance and displays marked vascular abnormalities and active metastasis. MicroRNAs (miRNAs) have been shown to play important roles in regulating tumor properties in cancer, however, whether miR-497 ...
Matching Content Categories {π}
- Education
- Science
- Movies
Content Management System {π}
What CMS is ncbi.nlm.nih.gov built with?
Custom-built
No common CMS systems were detected on Ncbi.nlm.nih.gov, and no known web development framework was identified.
Traffic Estimate {π}
What is the average monthly size of ncbi.nlm.nih.gov audience?
π Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 6,694,437 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Ncbi.nlm.nih.gov Make Money? {πΈ}
We donβt know how the website earns money.
Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Ncbi.nlm.nih.gov has a revenue plan, but it's either invisible or we haven't found it.
Keywords {π}
cells, hcc, doi, expression, cell, vegfa, aeg, figure, metastasis, huh, tumor, cancer, angiogenesis, pubmed, google, scholar, tissues, transfected, migration, pmc, invasion, carcinoma, staining, huvec, article, hepg, lines, free, hepatocellular, significantly, endothelial, overexpression, human, shown, data, mice, wang, liver, open, assay, lvmir, group, vitro, vivo, plcprf, formation, performed, mirnc, protein, lvmirnc,
Topics {βοΈ}
tgf-beta/smad3/nf-kappab signaling arsenic trioxide-induced anti-angiogenesis mir-nc/empty vector pcdna3 rabbit-anti-human-aeg-1-antibodies rabbit-anti-human-vegfa-antibodies rabbit-anti-human-cd34-antibodies enzyme-linked immunosorbent assay sybr green qrt-pcr sybr green qrtβpcr lv-mir-nc transfected huh7cells pluc-wt-aeg-1 group displayed pluc-wt-vegfa group displayed pmc beta search lentivirus-mediated antagomir expression recombinant lentivirus lv-mir-497 cancer-related deaths worldwide peroxidase-conjugated secondary antibody lv-mir-nc group pluc-mut-aeg-1 vector molecular mechanisms underlying anti-tube formation effect lv-mir-497 group showed control lv-mir-nc pathogen-free conditions anti-metastasis effects induced supplementary materials oncotarget-06-29527-s001 mir-497 suppresses pro-angiogenic serum-free medium inhibit pro-angiogenic activity serum free dmem pluc-mut-vegfa vectors lv-mir-497 transfected cells pmir-report system capillary tube formation endothelial recruitment assay hepatoma cell lines methods cell lines human hcc specimens sds-page gels primary antibodies overnight putative binding sequences Ξ²-actin rna primary tumor mass human microrna arrays Ξ²-galactosidase activities lv-mir-497 group hcc cell lines license information pmcid mapk/erk pathways onco targets ther
Social Networks {π}(6)
External Links {π}(77)
- How much money does https://doi.org/10.18632/oncotarget.5012 generate?
- Learn about the earnings of http://microRNA.org
- What is the monthly revenue of https://doi.org/10.3322/caac.21161?
- Monthly income for https://scholar.google.com/scholar_lookup?journal=CA%20Cancer%20J%20Clin&title=Recent%20progress%20in%20understanding,%20diagnosing,%20and%20treating%20hepatocellular%20carcinoma&author=M%20Maluccio&author=A%20Covey&volume=62&publication_year=2012&pages=394-399&pmid=23070690&doi=10.3322/caac.21161&
- How much income does https://doi.org/10.1016/j.cell.2011.02.013 have?
- Get to know https://scholar.google.com/scholar_lookup?journal=Cell&title=Hallmarks%20of%20cancer:%20the%20next%20generation&author=D%20Hanahan&author=RA%20Weinberg&volume=144&publication_year=2011&pages=646-674&pmid=21376230&doi=10.1016/j.cell.2011.02.013&'s earnings
- What's the monthly money flow for https://doi.org/10.1016/j.cell.2013.04.003?
- https://scholar.google.com/scholar_lookup?journal=Cell&title=The%20long%20and%20short%20of%20microRNA&author=LA%20Yates&author=CJ%20Norbury&author=RJ%20Gilbert&volume=153&publication_year=2013&pages=516-519&pmid=23622238&doi=10.1016/j.cell.2013.04.003&'s financial summary
- What's the revenue for https://doi.org/10.1002/emmm.201100209?
- What's https://scholar.google.com/scholar_lookup?journal=EMBO%20Mol%20Med&title=MicroRNA%20dysregulation%20in%20cancer:%20diagnostics,%20monitoring%20and%20therapeutics.%20A%20comprehensive%20review&author=MV%20Iorio&author=CM%20Croce&volume=4&publication_year=2012&pages=143-159&pmid=22351564&doi=10.1002/emmm.201100209&'s gross income?
- Explore the financials of https://doi.org/10.1261/rna.2384610
- How much income is https://scholar.google.com/scholar_lookup?journal=RNA&title=Mechanism%20of%20translational%20regulation%20by%20miR-2%20from%20sites%20in%20the%205%E2%80%B2%20untranslated%20region%20or%20the%20open%20reading%20frame&author=F%20Moretti&author=R%20Thermann&author=MW%20Hentze&volume=16&publication_year=2010&pages=2493-2502&pmid=20966199&doi=10.1261/rna.2384610& earning monthly?
- What's the financial intake of https://doi.org/10.1371/journal.pone.0009429?
- Monthly income for https://scholar.google.com/scholar_lookup?journal=PLoS%20ONE&title=miR-24%20regulates%20apoptosis%20by%20targeting%20the%20open%20reading%20frame%20(ORF)%20region%20of%20FAF1%20in%20cancer%20cells&author=W%20Qin&author=Y%20Shi&author=B%20Zhao&author=C%20Yao&author=L%20Jin&volume=5&publication_year=2010&pages=e9429&pmid=20195546&doi=10.1371/journal.pone.0009429&
- Monthly income for https://doi.org/10.2147/OTT.S36161
- Check the income stats for https://scholar.google.com/scholar_lookup?journal=Onco%20Targets%20Ther&title=Role%20of%20microRNAs%20in%20hepatocellular%20carcinoma:%20a%20clinical%20perspective&author=E%20Callegari&author=BK%20Elamin&author=S%20Sabbioni&author=L%20Gramantieri&author=M%20Negrini&volume=6&publication_year=2013&pages=1167-1178&pmid=24039437&doi=10.2147/OTT.S36161&
- How much does https://scholar.google.com/scholar_lookup?journal=Int%20J%20Clin%20Exp%20Pathol&title=Down-regulation%20of%20miR-497%20is%20associated%20with%20poor%20prognosis%20in%20renal%20cancer&author=X%20Zhao&author=Z%20Zhao&author=W%20Xu&author=J%20Hou&author=X%20Du&volume=8&publication_year=2015&pages=758-764&pmid=25755771& make?
- How much profit is https://doi.org/10.3892/or.2014.3439 making per month?
- How much profit is https://scholar.google.com/scholar_lookup?journal=Oncol%20Rep&title=MicroRNA-497%20suppresses%20angiogenesis%20by%20targeting%20vascular%20endothelial%20growth%20factor%20A%20through%20the%20PI3K/AKT%20and%20MAPK/ERK%20pathways%20in%20ovarian%20cancer&author=W%20Wang&author=F%20Ren&author=Q%20Wu&author=D%20Jiang&author=H%20Li&volume=32&publication_year=2014&pages=2127-2133&pmid=25176450&doi=10.3892/or.2014.3439& making per month?
- How much does https://doi.org/10.18632/oncotarget.2184 bring in each month?
- What's the profit of https://scholar.google.com/scholar_lookup?journal=Oncotarget&title=MiR-497%20downregulation%20contributes%20to%20the%20malignancy%20of%20pancreatic%20cancer%20and%20associates%20with%20a%20poor%20prognosis&author=J%20Xu&author=T%20Wang&author=Z%20Cao&author=H%20Huang&author=J%20Li&volume=5&publication_year=2014&pages=6983-6993&pmid=25149530&doi=10.18632/oncotarget.2184&?
- How much does https://doi.org/10.1007/s12032-014-0844-4 generate monthly?
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Med%20Oncol&title=Checkpoint%20kinase%201%20is%20negatively%20regulated%20by%20miR-497%20in%20hepatocellular%20carcinoma&author=Y%20Xie&author=RR%20Wei&author=GL%20Huang&author=MY%20Zhang&author=YF%20Yuan&volume=31&publication_year=2014&pages=844&pmid=24464213&doi=10.1007/s12032-014-0844-4&?
- What's the total monthly financial gain of https://doi.org/10.1371/journal.pone.0060155?
- How much does https://scholar.google.com/scholar_lookup?journal=PLoS%20One&title=The%20tumor-suppressive%20miR-497%E2%80%93195%20cluster%20targets%20multiple%20cell-cycle%20regulators%20in%20hepatocellular%20carcinoma&author=M%20Furuta&author=K%20Kozaki&author=K%20Tanimoto&author=S%20Tanaka&author=S%20Arii&volume=8&publication_year=2013&pages=e60155&pmid=23544130&doi=10.1371/journal.pone.0060155& earn?
- What's the monthly income of https://doi.org/10.1038/onc.2011.500?
- Profit of https://scholar.google.com/scholar_lookup?journal=Oncogene&title=MicroRNA-375%20targets%20AEG-1%20in%20hepatocellular%20carcinoma%20and%20suppresses%20liver%20cancer%20cell%20growth%20in%20vitro%20and%20in%20vivo&author=XX%20He&author=Y%20Chang&author=FY%20Meng&author=MY%20Wang&author=QH%20Xie&volume=31&publication_year=2012&pages=3357-3369&pmid=22056881&doi=10.1038/onc.2011.500&
- Earnings of https://doi.org/10.1002/ar.20668
- What's the revenue for https://scholar.google.com/scholar_lookup?journal=Anat%20Rec%20(Hoboken)&title=Vascular%20changes%20in%20hepatocellular%20carcinoma&author=ZF%20Yang&author=RT%20Poon&volume=291&publication_year=2008&pages=721-734&pmid=18484619&doi=10.1002/ar.20668&?
- How much profit does https://doi.org/10.1080/10739680802095964 make?
- How much does https://scholar.google.com/scholar_lookup?journal=Microcirculation&title=Systems%20biology%20of%20vascular%20endothelial%20growth%20factors&author=F%20Mac%20Gabhann&author=AS%20Popel&volume=15&publication_year=2008&pages=715-738&pmid=18608994&doi=10.1080/10739680802095964& pull in?
- How profitable is https://doi.org/10.1016/B978-0-12-401676-7.00007-3?
- How much revenue does https://scholar.google.com/scholar_lookup?journal=Adv%20Cancer%20Res&title=AEG-1/MTDH/LYRIC%20in%20liver%20cancer&author=D%20Sarkar&volume=120&publication_year=2013&pages=193-221&pmid=23889992&doi=10.1016/B978-0-12-401676-7.00007-3& bring in?
- How much does https://doi.org/10.1126/scisignal.2005825 pull in monthly?
- What is the earnings of https://scholar.google.com/scholar_lookup?journal=Sci%20Signal&title=Dysregulation%20of%20microRNA%20biogenesis%20and%20gene%20silencing%20in%20cancer&author=A%20Hata&author=J%20Lieberman&volume=8&publication_year=2015&pages=re3&pmid=25783160&doi=10.1126/scisignal.2005825&?
- What's the profit of https://doi.org/10.5858/2000-124-1061-IEOVEG?
- Income figures for https://scholar.google.com/scholar_lookup?journal=Arch%20Pathol%20Lab%20Med&title=Increased%20expression%20of%20vascular%20endothelial%20growth%20factor%20and%20angiogenesis%20in%20the%20early%20stage%20of%20multistep%20hepatocarcinogenesis&author=YN%20Park&author=YB%20Kim&author=KM%20Yang&author=C%20Park&volume=124&publication_year=2000&pages=1061-1065&pmid=10888784&doi=10.5858/2000-124-1061-IEOVEG&
- What's the financial intake of https://doi.org/10.1016/s0168-8278(97)80323-6?
- What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=J%20Hepatol&title=Increased%20expression%20of%20vascular%20endothelial%20growth%20factor%20in%20human%20hepatocellular%20carcinoma&author=H%20Miura&author=T%20Miyazaki&author=M%20Kuroda&author=T%20Oka&author=R%20Machinami&volume=27&publication_year=1997&pages=854-861&pmid=9382973&doi=10.1016/s0168-8278(97)80323-6&?
- How much profit does https://doi.org/10.1002/hep.26373 make?
- Get to know what's the income of https://scholar.google.com/scholar_lookup?journal=Hepatology&title=MicroRNA-195%20suppresses%20angiogenesis%20and%20metastasis%20of%20hepatocellular%20carcinoma%20by%20inhibiting%20the%20expression%20of%20VEGF,%20VAV2,%20and%20CDC42&author=R%20Wang&author=N%20Zhao&author=S%20Li&author=JH%20Fang&author=MX%20Chen&volume=58&publication_year=2013&pages=642-653&pmid=23468064&doi=10.1002/hep.26373&
- How profitable is https://doi.org/10.1186/s12967-014-0259-1?
- How much does https://scholar.google.com/scholar_lookup?journal=J%20Transl%20Med&title=MiR-126-3p%20suppresses%20tumor%20metastasis%20and%20angiogenesis%20of%20hepatocellular%20carcinoma%20by%20targeting%20LRP6%20and%20PIK3R2&author=C%20Du&author=Z%20Lv&author=L%20Cao&author=C%20Ding&author=OA%20Gyabaah&volume=12&publication_year=2014&pages=259&pmid=25240815&doi=10.1186/s12967-014-0259-1& net monthly?
- https://doi.org/10.1016/j.toxlet.2014.08.024's revenue stream
- Income figures for https://scholar.google.com/scholar_lookup?journal=Toxicol%20Lett&title=Inhibition%20of%20TGF-beta/SMAD3/NF-kappaB%20signaling%20by%20microRNA-491%20is%20involved%20in%20arsenic%20trioxide-induced%20anti-angiogenesis%20in%20hepatocellular%20carcinoma%20cells&author=F%20Jiang&author=X%20Wang&author=Q%20Liu&author=J%20Shen&author=Z%20Li&volume=231&publication_year=2014&pages=55-61&pmid=25196641&doi=10.1016/j.toxlet.2014.08.024&
- What's the financial intake of https://doi.org/10.1016/s0092-8674(00)81683-9?
- How much does https://scholar.google.com/scholar_lookup?journal=Cell&title=The%20hallmarks%20of%20cancer&author=D%20Hanahan&author=RA%20Weinberg&volume=100&publication_year=2000&pages=57-70&pmid=10647931&doi=10.1016/s0092-8674(00)81683-9& generate monthly?
- How much does https://doi.org/10.1371/journal.pone.0120969 pull in monthly?
- How much does https://scholar.google.com/scholar_lookup?journal=PLoS%20One&title=miR-29a/b%20Enhances%20Cell%20Migration%20and%20Invasion%20in%20Nasopharyngeal%20Carcinoma%20Progression%20by%20Regulating%20SPARC%20and%20COL3A1%20Gene%20Expression&author=F%20Qiu&author=R%20Sun&author=N%20Deng&author=T%20Guo&author=Y%20Cao&volume=10&publication_year=2015&pages=e0120969&pmid=25786138&doi=10.1371/journal.pone.0120969& make?
- How much cash flow does https://doi.org/10.1016/j.bbrc.2014.05.053 have monthly?
- How much profit does https://scholar.google.com/scholar_lookup?journal=Biochem%20Biophys%20Res%20Commun&title=MicroRNA-497%20inhibition%20of%20ovarian%20cancer%20cell%20migration%20and%20invasion%20through%20targeting%20of%20SMAD%20specific%20E3%20ubiquitin%20protein%20ligase%201&author=W%20Wang&author=F%20Ren&author=Q%20Wu&author=D%20Jiang&author=H%20Li&volume=449&publication_year=2014&pages=432-437&pmid=24858688&doi=10.1016/j.bbrc.2014.05.053& make?
- Financial intake of https://doi.org/10.1016/j.bbrc.2014.05.011
- What's the profit of https://scholar.google.com/scholar_lookup?journal=Biochem%20Biophys%20Res%20Commun&title=The%20putative%20tumor%20suppressor%20microRNA-497%20modulates%20gastric%20cancer%20cell%20proliferation%20and%20invasion%20by%20repressing%20eIF4E&author=W%20Li&author=X%20Jin&author=X%20Deng&author=G%20Zhang&author=B%20Zhang&volume=449&publication_year=2014&pages=235-240&pmid=24845562&doi=10.1016/j.bbrc.2014.05.011&?
- How much does https://doi.org/10.4161/cc.28607 gross monthly?
- https://scholar.google.com/scholar_lookup?journal=Cell%20Cycle&title=Knockdown%20of%20astrocyte%20elevated%20gene-1%20(AEG-1)%20in%20cervical%20cancer%20cells%20decreases%20their%20invasiveness,%20epithelial%20to%20mesenchymal%20transition,%20and%20chemoresistance&author=X%20Liu&author=D%20Wang&author=H%20Liu&author=Y%20Feng&author=T%20Zhu&volume=13&publication_year=2014&pages=1702-1707&pmid=24675891&doi=10.4161/cc.28607&'s financial summary
- How much does https://doi.org/10.1016/j.humpath.2013.08.030 bring in each month?
- How much does https://scholar.google.com/scholar_lookup?journal=Hum%20Pathol&title=Expression%20of%20AEG-1%20and%20microvessel%20density%20correlates%20with%20metastasis%20and%20prognosis%20of%20oral%20squamous%20cell%20carcinoma&author=X%20Xia&author=R%20Du&author=L%20Zhao&author=W%20Sun&author=X%20Wang&volume=45&publication_year=2014&pages=858-865&pmid=24656097&doi=10.1016/j.humpath.2013.08.030& generate monthly?
- Monthly income for https://doi.org/10.1186/1476-4598-12-109
- What is the earnings of https://scholar.google.com/scholar_lookup?journal=Mol%20Cancer&title=Astrocyte%20elevated%20gene-1%20is%20associated%20with%20metastasis%20in%20head%20and%20neck%20squamous%20cell%20carcinoma%20through%20p65%20phosphorylation%20and%20upregulation%20of%20MMP1&author=YP%20Wang&author=IJ%20Liu&author=CP%20Chiang&author=HC%20Wu&volume=12&publication_year=2013&pages=109&pmid=24063540&doi=10.1186/1476-4598-12-109&?
- What's the monthly money flow for https://doi.org/10.1093/nar/gkm971?
- Learn about the earnings of https://scholar.google.com/scholar_lookup?journal=Nucleic%20Acids%20Res&title=Lentivirus-mediated%20antagomir%20expression%20for%20specific%20inhibition%20of%20miRNA%20function&author=M%20Scherr&author=L%20Venturini&author=K%20Battmer&author=M%20Schaller-Schoenitz&author=D%20Schaefer&volume=35&publication_year=2007&pages=e149&pmid=18025036&doi=10.1093/nar/gkm971&
- What is the earnings of https://doi.org/10.18632/oncotarget.2988?
- How much does https://scholar.google.com/scholar_lookup?journal=Oncotarget&title=Functional%20repair%20of%20p53%20mutation%20in%20colorectal%20cancer%20cells%20using%20trans-splicing&author=X%20He&author=J%20Liao&author=F%20Liu&author=J%20Yan&author=H%20Shang&volume=6&publication_year=2015&pages=2034-2045&pmid=25576916&doi=10.18632/oncotarget.2988& generate monthly?
- What's the monthly income of https://doi.org/10.1038/srep08705?
- Find out how much https://scholar.google.com/scholar_lookup?journal=Sci%20Rep&title=Trans-splicing%20repair%20of%20mutant%20p53%20suppresses%20the%20growth%20of%20hepatocellular%20carcinoma%20cells%20in%20vitro%20and%20in%20vivo&author=X%20He&author=F%20Liu&author=J%20Yan&author=Y%20Zhang&author=H%20Shang&volume=5&publication_year=2015&pages=8705&pmid=25732051&doi=10.1038/srep08705& earns monthly
- Find out how much https://github.com/ncbi earns monthly
- How much does https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323 make?
- Financial intake of https://www.nlm.nih.gov/web_policies.html
- https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office's total income per month
- What's the financial outcome of https://www.hhs.gov/vulnerability-disclosure-policy/index.html?
- What are the total earnings of https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Ajournal?
- Get to know what's the income of https://www.nlm.nih.gov/accessibility.html
- How much profit does https://www.nlm.nih.gov/careers/careers.html generate?
- How much does https://www.nlm.nih.gov/ rake in every month?
- How much does https://www.nih.gov/ bring in each month?
- How much money does https://www.hhs.gov/ generate?
- Learn how profitable https://www.usa.gov/ is on a monthly basis
Analytics and Tracking {π}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {π}
- jQuery
- jQuery module (jquery-3.6.0)
Emails and Hosting {βοΈ}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {π¦}
- Ncbi