
NCBI . NLM . NIH . GOV {
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Title[redir]:
Treatment of renal fibrosis by rebalancing TGF-β/Smad signaling with the combination of asiatic acid and naringenin - PMC
Description:
We recently showed that imbalance of TGF-β/Smad signaling with over-activation of Smad3 but lower levels of Smad7 is a central mechanism of tissue fibrosis. In the present study, we report here that inhibition of Smad3 with naringenin (NG) and ...
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Keywords {🔍}
smad, doi, fibrosis, renal, combination, effect, signaling, pubmed, google, scholar, kidney, expression, treatment, uuo, figure, mice, tgfβsmad, tgfβ, pmc, lan, inhibition, article, mrna, free, inhibitory, vitro, collagen, phosphorylation, compared, journal, huang, mouse, nephropathy, protein, levels, study, model, inhibits, dosages, realtime, pcr, analysis, western, αsma, meng, inhibitor, disease, inhibiting, cytotoxicity, dmso,
Topics {✒️}
tgf-beta/smad3-mediated renal fibrosis smad4 impairs tgf-beta/smad3 inhibiting tgf-beta-induced epithelial downstream tgf-β/smad signaling inhibit tgf-β/smad signaling tgf-beta/bmp-7/smad pathways blocking tgf-beta/smad signaling inhibit tgf-β/smad3 signaling sp1-tgf-beta/smad3-nf rebalancing tgf-β/smad signaling anti-tgf-β antibody produces tgf-beta receptor ii tgf-β1-induced fibrotic response block tgf-β1-induced activation blocking tgf-β1-induced phosphorylation inhibiting tgf-β1-induced fibrosis tgf-beta/smad signaling tgf-beta1/smad3 signaling protects tgf-β/smad signaling pmc beta search real-time pcr detects tukey post-hoc tests tgf-β/smad3 signaling tgf-β1/smad signaling recombinant human tgf-β1 12/12-hour light/dark cycle end-stage renal disease 5 mg/kg/boy weight streptozotocin-induced diabetic nephropathy tgf-β1-induced phosphorylation real-time pcr show tgf-β1-stimulated tecs phospho-smad3 nuclear translocation tgf-β1-induced collagen tgf-beta type develop anti-fibrosis therapy tgf-β receptor tgf-β type tgf-β signaling tgf-β1 mrna expression ubiquitin-dependent degradation contributes gene transfer dose-independently inhibited collagen quantitative image-analysis system publisher site pdf inhibits smad3 signaling tgf-β/smads traditional chinese medicine license information pmcid ii receptor kinases
Questions {❓}
- How does TGF-beta mediate tubulointerstitial fibrosis?
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- https://doi.org/10.1681/ASN.2010121308's total income per month
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