
NCBI . NLM . NIH . GOV {
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Title[redir]:
Dissecting tRNA-derived fragment complexities using personalized transcriptomes reveals novel fragment classes and unexpected dependencies - PMC
Description:
We analyzed transcriptomic data from 452 healthy men and women representing five different human populations and two races, and, 311 breast cancer samples from The Cancer Genome Atlas. Our studies revealed numerous constitutive, distinct fragments ...
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Keywords {🔍}
fragments, trna, doi, trfs, datasets, figure, google, scholar, pubmed, pmc, article, trnas, breast, free, mitochondrial, abundance, itrfs, anticodon, rna, internal, fragment, cell, length, supplementary, lcl, cancer, normal, mature, brca, nuclear, lengths, differences, dataset, genomic, tumor, reads, analysis, tissue, expression, human, profiles, genome, data, mers, sequence, shown, distinct, anticodons, specific, population,
Topics {✒️}
stress-induced trna-derived rnas parametric mann-witney u-test post-transcriptionally added cca-tail ago hits-clip-seq dataset mann-witney u-test mann-whitney u-test tissue-state-specific mrna “signatures” pmc beta search dicer-dependent small rnas fragment-specific pcr-based validation 78 triple-negative-breast-cancer datasets ago clip-seq data ebv-immortalized b-cells ago hits-clip datasets mining clip-seq data high-throughput biomolecule analysis orange-colored labels mark gender-/population-/race-dependent difference starvation-induced cleavage short rna-seq profiles race-dependent abundance profiles 5′-trf ggggaattagctcaag-t-ggtagagcgcttgct triple-negative breast cancer estrogen receptor status progesterone receptor status short-rna sequencing profiles [google scholar] 46 transfer rna-derived fragments maps rna-seq data tissue-specific mrna “signatures” �short” rna-seq datasets human mt4 t-cells human chromosome assembly terms “trna-derived fragments” gggggtgtag-c-tcagtggtaga trfs exhibit gender-dependencies semi-mature trna molecule supplementary materials oncotarget-06-24797-s001 inhibit protein translation reflecting disease-subtype specificity trna-derived fragments target trna-derived rna fragments ago clip-seq gender-specific trna profiles exhibit functional properties present multi-faceted evidence trna-scan-se database [54] examined differential ago-loading ggggaattagctcaag-n-ggtagagcgcttgct ago-loaded trna fragments
Questions {❓}
- Mitochondrial tRNA-lookalikes in nuclear chromosomes: Could they be functional?
- Triple positive breast cancer: A distinct subtype?
- What is our definition of tRNA space?
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