
NCBI . NLM . NIH . GOV {
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Title[redir]:
Intracellular annexin A2 regulates NF-κB signaling by binding to the p50 subunit: implications for gemcitabine resistance in pancreatic cancer - PMC
Description:
Annexin A2 (ANXA2) expression is highly upregulated in many types of cancer. Although cell surface localization of ANXA2 has been reported to have a critical role in the progression and metastasis of a variety of tumors, including pancreatic cancer, ...
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Keywords {🔍}
anxa, cells, nfκb, cancer, cell, doi, expression, pubmed, google, scholar, figure, activity, pancreatic, resistance, transcriptional, tnfα, data, gemcitabine, interaction, treatment, signaling, annexin, subunit, antiapoptotic, wildtype, pmc, role, genes, effects, drug, usa, target, hela, intracellular, miapaca, expressing, supplementary, kim, article, tumor, protein, control, assay, nucleus, increased, secretion, proteins, endogenous, human, binding,
Topics {✒️}
phorbol 12-myristate 13-acetate phosphate-buffered saline short hairpin rna tumor necrosis factor-α c-terminal flag-tagged anxa2 pretrox-ires-zsgreen1-cflag-anxa2 pretrox-ires-zsgreen1 vector n-terminal deletion mutant poly adp-ribose polymerase ectopically expressing wild-type mia-paca2 cells exhibited viable mia-paca2 cells human monocyte-derived macrophages anti-rabbit preimmune igg pmc beta search rabbit anti-nf-κb p50 cells expressing wild-type c-terminal-tagged anxa2 ni-nta-agarose beads anti-apoptotic gene products functional n-terminal domain show potent anti-angiogenic glutathione s-transferase induced akt/mtor signaling pathway macrophage tnf-α enhance tissue-type plasminogen activator protein-agarose bead complexes nf-κb signaling pathways enzyme-linked immunosorbent assay trigger nf-κb signaling nf-κb target genes ni-nta lysis buffer plasmin/plasminogen activator system methods cell lines nf-κb signaling pathway wild-type cflag-anxa2 tk-renilla luciferase plasmid fluorescence-activated cell sorting activate nf-κb signaling anti-apoptotic gene mcl-1 anti-apoptotic gene expression multi-drug resistance phenotype plasmin-treated human macrophages anti-inflammatory drugs binds stimulate anxa2-dependent secretion stimulates nf-κb activity nf-κb-specific inhibitor tnf-α-induced apoptosis gemcitabine-induced cell death nf-κb transcriptional assay
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