
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Acquisition of cancer stem cell-like properties in non-small cell lung cancer with acquired resistance to afatinib - PMC
Description:
Afatinib is an irreversible epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) that is known to be effective against the EGFR T790M variant, which accounts for half of the mechanisms of acquired resistance to reversible ...
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Keywords {🔍}
cell, doi, cancer, lines, resistance, hccar, afatinib, cells, egfr, google, scholar, lung, pubmed, stem, acquired, hcc, sublines, pmc, met, afatinibresistant, mutation, article, line, growth, celllike, emt, free, properties, established, parental, hccacr, egfrtkis, usa, shown, fig, factor, displayed, amplification, patients, inhibitor, mechanisms, study, mutations, crizotinib, drug, receptor, kinase, markers, exposure, expression,
Topics {✒️}
t790m-mutant egfr-selective egfr-tkis specific pathogen-free conditions egfr-tki-resistant cell lines quantitative reverse transcription-pcr receptor tyrosine kinase small-cell lung cancer tyrosine kinase inhibitor cancer-related death worldwide ultra-low attachment surface pmc beta search stem cell-related markers receptor tyrosine kinases glyceraldehyde-3-phosphate dehydrogenase phospho-p44/p42 mapk tyrosine kinase inhibitors delta-delta-ct method monoclonal anti-actin antibody afatinib-resistant cell lines cell lines including met amplified-cell lines egfr-tki-resistant cells cell growth assay real-time pcr egfr mutant nsclc met-amplified cell line reversible egfr-tki treatment l858r/t790m mutations inhibiting egfr-akt signaling overcomes t790m-mediated resistance drug-free condition soft agar assay western blot analysis hcc827-acr cell line nsclc cell lines crizotinib-resistant cell line egfr kinase domain activating egfr mutations exhibit aldh1 expression methods cell lines cell aggregates occupying copy number gains established afatinib-resistant cells parental cell lines anti-aldh1 antibody egfr t790m mutations afatinib-resistant sublines established acquired afatinib-resistant sublines relative copy number ar2 displayed downregulation cancer stem cell
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- How much does https://www.hhs.gov/vulnerability-disclosure-policy/index.html generate monthly?
- Income figures for https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Ajournal
- What is the earnings of https://www.nlm.nih.gov/accessibility.html?
- How much does https://www.nlm.nih.gov/careers/careers.html bring in each month?
- Income figures for https://www.nlm.nih.gov/
- https://www.nih.gov/'s financial summary
- What are the total earnings of https://www.hhs.gov/?
- What are the total earnings of https://www.usa.gov/?
Analytics and Tracking {📊}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {📚}
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi