
NCBI . NLM . NIH . GOV {
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Title[redir]:
Molecular Pathways: Activating T Cells After Cancer Cell Phagocytosis from Blockade of CD47 “Don’t Eat Me” Signals - PMC
Description:
Recent advances with immunotherapy agents for the treatment of cancer has provided remarkable, and in some cases, curative results. Our laboratory has identified CD47 as an important “don’t eat me” signal expressed on malignant cells. Blockade of ...
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Keywords {🔍}
cells, doi, tumor, cell, pubmed, google, scholar, anticd, pmc, cancer, immune, article, free, antibody, phagocytosis, macrophages, antitumor, blockade, adaptive, antibodies, response, innate, combination, antigen, blocking, agents, cdsirpα, increase, therapy, tumors, total, blood, human, eat, additional, vivo, sirpα, apcs, immunity, studies, removal, targeting, therapies, volkmer, nlm, dont, present, activation, mhc, potential,
Topics {✒️}
cd47-signal regulatory protein-alpha anti-cd47 antibody-mediated phagocytosis high-affinity cd47 ectodomain pmc beta search antitumor t-cell immunity anti-cd47/anti-cd40 combination signal regulatory protein-α dominant pro-phagocytic signal immunoreceptor tyrosine-based inhibition synergistic anti-tumor responses lasting anti-viral responses current pre-clinical data adaptive anti-tumor immunity cells recognize neo-antigens anti-cd47 antibody therapy maximum anti-tumor response anti-cd47 antibody synergizes remaining anti-cd47 therapy cytotoxic t-cell response sirp-α axis results phagocytosis/tumor cell removal sirp-α blockade primes dependent tumor targeting adverse prognostic factor sirp-α itim motifs sirp-α engagement results anti-cd47 blocking antibodies footnotes disclosure acute myelogenous leukemia antibody therapy targeting cross-present ova peptides publisher site pdf vivo pre-clinical evaluation tumor neo-antigens therapeutic antibody targeting low mutation loads total anti-tumor bypasses t-cell clin cancer res checkpoint inhibitor blocks lasting anti-tumor reducing total phagocytosis phagocytosed tumor antigens planned clinical trials tumor cell phagocytosis sirp-α axis red blood cells allowing selective cytotoxicity aggressive metastatic leiomyosarcoma anti-cd47 antibody
Questions {❓}
- Will CD47 blockade provide sufficient T cell priming in an un-defined tumor antigen or in those tumors with moderate to low mutation loads?
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- How much does https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Amanuscript rake in every month?
- What's the financial gain of https://www.nlm.nih.gov/accessibility.html?
- How much revenue does https://www.nlm.nih.gov/careers/careers.html generate?
- What's the financial intake of https://www.nlm.nih.gov/?
- What's the income generated by https://www.nih.gov/ each month?
- What's the financial outcome of https://www.hhs.gov/?
- https://www.usa.gov/'s revenue stream
Analytics and Tracking {📊}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {📚}
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi