
NCBI . NLM . NIH . GOV {
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Title[redir]:
Diversity in mechanism and function of tRNA methyltransferases - PMC
Description:
tRNA molecules undergo extensive post-transcriptional processing to generate the mature functional tRNA species that are essential for translation in all organisms. These processing steps include the introduction of numerous specific chemical ...
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Keywords {🔍}
trna, google, scholar, doi, pmid, pubmed, httpdxdoiorg, trm, methylation, pmc, article, free, methyltransferase, rna, methyltransferases, substrate, enzymes, modification, enzyme, mechanism, recognition, biol, formation, human, methyl, cerevisiae, structure, specificity, function, base, trnas, family, protein, catalytic, grosjean, group, complex, fig, position, general, acids, members, structural, mol, nucleotide, target, identified, sam, catalyzes, proposed,
Topics {✒️}
s-adenosyl-l-methionine pmc beta search carboxy-s-adenosyl methionine a37 deaminase tad2/tad3 bifunctional methyltransferase–extensive moonlighting divalent metal ion-dependent autosomal-recessive intellectual disability watson-crick base pairing wild-type cells grown actin-binding protein abp140 s-adenosylmethionine-dependent methyltransferase folate-dependent trna methyltransferase [google scholar] 6 trna anti-codon loop t-stem trna analog x-ray crystal structure homologous 2'-o-methyltransferases showing dictyostelium discoideum dnmt2-homologue bacterial ruma-type trna sam-dependent trna methyltransferases anticodon stem-loop structure initial reports centered highly trna species-specific rapid trna decay multisite-specific trna methyltransferase highly diverse pathway abolish trm6/trm61 formation slow growth phenotype dual-specific enzyme responsible m1a58 methyltransferase trm6/trm61 folate-dependent trna sequence-structure-function relationships processing steps include full-length trna gcd10p/gcd14p complex divalent metal ion thermus thermophilus hb27 positively charged surface covalent enzyme-nucleotide intermediate trm6/trm61 complex responsible positively charged species protein partnership discovered nuclear trm5-catalyzed modification induced fit processes dictyostelium discoideum dnmt2 human disease syndromes united states government distantly-related member hypomodified initiator trnamet primary microcephaly
Questions {❓}
- A primordial tRNA modification required for the evolution of life?
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- https://doi.org/10.1074/jbc.M110.113100 income
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