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Keywords {🔍}

doi, mitochondrial, trmt, pubmed, google, scholar, figure, pmc, article, modification, free, trna, human, variants, protein, individuals, mutations, rna, genet, cells, mttrna, activity, affected, age, data, hum, rtpex, showed, site, muscle, model, trnas, mtdna, disease, control, trm, clinical, methyltransferase, cardiomyopathy, detected, translation, performed, complex, respiratory, gene, residues, values, score, pmetval, fibroblasts,

Topics {✒️}

acid-base proton-transfer reaction multiple respiratory-chain deficiencies e-rare project genomit mitochondrial-trna-modifying enzymes vital interventricular septum-wall diameter tissue-specific threshold effects human respiratory-chain deficiencies dttp-induced stalling intensity post-transcriptional modification pattern engineered zinc-finger proteins pmc beta search similar steady-state levels web resources rt-pex reactions preformed cdk5rap1-mediated 2-methylthio modification adomet-dependent methyltransferases superfamily figures s1–s6 mmc1 n6-2-methylthio-n6-threonylcarbamoyladenosine 6-day sirna-mediated depletion pmc copyright notice mitochondrial-trna modifier mto1 respiratory-chain complexes lead mt-trna modification deficiencies rt-pex reaction readthrough rt-pex experiment performed mt-trna modifying factors amino-acid residues affected rt-pex reactions performed modified mt-trna positions vivo aa-trna selection post-transcriptional processing post-transcriptional modifications outer-membrane protein tom22 highly specialized mechanisms rt-pex assay performed histo-chemical cox defect blocking base pairing showed slight dystrophy supplemental data include supplemental data mmc2 post-transcriptional modification respiratory-chain analysis mt-trna anticodon loop mitochondrial disease-causing factors methanocaldococcus jannaschii atrm5–trnacys rt-pex pausing license information pmcid skeletal-muscle biopsy samples sirna-induced depletion affect mt-trna modification

Questions {❓}

• A primordial tRNA modification required for the evolution of life?

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