
NCBI . NLM . NIH . GOV {
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Title[redir]:
Connecting Mitochondria, Metabolism, and Stem Cell Fate - PMC
Description:
As sites of cellular respiration and energy production, mitochondria play a central role in cell metabolism. Cell differentiation is associated with an increase in mitochondrial content and activity and with a metabolic shift toward increased ...
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Keywords {π}
mitochondrial, differentiation, stem, cells, cell, doi, pubmed, google, scholar, pmc, article, free, pluripotency, metabolism, ros, mitochondria, reprogramming, metabolic, biogenesis, activity, embryonic, mouse, expression, glycolysis, function, increased, regulation, oxygen, human, mtorc, ipscs, oxphos, mescs, production, role, energy, levels, involved, ampk, pluripotent, pathways, complex, fate, hescs, required, protein, somatic, signaling, pscs, activation,
Topics {βοΈ}
peroxisome proliferator-activated receptor catalytic Ξ²-f1-atpase subunit c-jun n-terminal kinases akt1/akt2 double-deficient mhscs protein kinase c-lambda/iota author disclosure statement amp-activated protein kinase single-cell transcriptome analysis adenoviral-mediated pgc-1alpha overexpression carbonyl cyanide m-chlorophenylhydrazone lineage-restricted progenitor cells wnt/Ξ²-catenin signaling myocyte enhancer factor-2c nad-dependent histone deacetylase pmc beta search longevity-promoting compounds enhance tissue-specific progenitor cells increased superoxide flashes tgf-beta1 induces senescence pgc-1alpha-dependent mechanism adenylate kinase isoforms rat neural progenitors es-cell-derived cardiomyogenesis pten-loss-evoked leukemogenesis adipose-derived stem cells high amp/atp ratio multiple post-translational modifications mtor supports long-term amp/atp ratio increases pgc-1alpha mediates differentiation ca2+/calcineurin signaling pathway mammalian ampk-related kinases tsc-mtor maintains quiescence oxygen-regulated Ξ± subunit superoxide radical anion mitochondrial-dependent biological processes umbilical cord-derived mscs hypoxia-inducible factor 1alpha long-term reconstitution ability gamma coactivator-1Ξ± environment-sensing pathways regulate vitro lineage-directed differentiation glycolytic-based metabolism represents glycolysis-based metabolism favored reactive oxygen species induced pluripotent stem publisher site pdf haematopoietic stem cells liver kinase b1 stem cell differentiation/reprogramming
Questions {β}
- Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?
- Next, we address 3 questions: (i) What advantages does glycolysis bestow on PSCs?
- Noncoding RNAs: a new way to decode the interplay between mitochondria and cell differentiation?
- This leads to a complex and still unresolved question: Is the mitochondrial biogenesis initiated first, followed by a loss of pluripotency and a commitment to differentiation, which is further accompanied by increased mitochondrial function?
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Analytics and Tracking {π}
- Google Analytics
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Libraries {π}
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Emails and Hosting {βοΈ}
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