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Title[redir]:
NF-κB activation in human breast cancer specimens and its role in cell proliferation and apoptosis - PMC
Description:
Lack of molecular targets in estrogen receptor-negative (ER-negative) breast cancer is a major therapeutic hurdle. We studied NF-κB activation in human breast tumors and in carcinoma cell lines. Activated NF-κB was detected predominantly in ...
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Keywords {🔍}
nfκb, cells, cell, fig, breast, cancer, activation, pubmed, google, scholar, doi, nbd, tumors, class, heregulin, proliferation, treatment, human, tumor, erbb, activated, cancers, epithelial, medium, ernegative, nuclear, pmc, skbr, detected, antibodies, shown, activity, serumfree, apoptosis, article, nuclei, growth, inhibition, heregulininduced, tissue, bot, results, herceptin, receptor, mutant, free, erpositive, active, samples, signaling,
Topics {✒️}
heregulin-stimulated nf-κb–32p–dna-binding activity nf-κb–32p–dna-binding activity supershifted 32p–nf-κb–dna complexes elevated nf-κb–dna-binding activity rhodamine red-conjugated anti-p50 dana–farber/harvard specialized programs er-negative/erbb2-positive tumor samples 32p–nf-κb–dna complex nf-κb–dna-binding activity fitc-conjugated anti-p65 antibodies er-negative/erbb2-positive subclass heregulin-stimulated nf-κb activation heregulin-induced nf-κb activation nf-κb–dna complex detected positive dna-binding activity 32p–dna–protein complex show dna-binding activity er-negative/erbb2-negative dana–farber cancer institute er-negative/erbb2-positive er-positive/erbb2-negative er-negative breast cancers nf-κb essential modulator rel-family proteins p50 er-positive/erbb2-positive nf-κb-negative samples er-positive breast cancers nf-κb activation status induce nf-κb activation involve nf-κb activation nf-κb activation plays nf-κb activation influencing elevating nf-κb activation active nf-κb complex electrophoretic mobility-shift assay fitc-conjugated antibody pmc beta search implicating activated nf-κb activated nf-κb qualify harbor activated nf-κb nf-κb stimulates proliferation e2-induced cell proliferation er-positive breast tumors results qualify nf-κb blocked heregulin-mediated activation red fluorescence-emitting nuclei anti-rel protein antibodies heregulin-stimulated growth contributed dna-binding activity p50–p65 complex bound
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