
NCBI . NLM . NIH . GOV {
}
Title[redir]:
CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages - PMC
Description:
Kitamura et al. find a role for metastasis-associated macrophage (MAM) chemokine pathways CCL2–CCR2 and CCL3–CCR1 in promoting breast cancer cell pulmonary metastasis. Genetic deletion of CCR1 or CCL3 in a mouse model of breast cancer cell ...
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Keywords {🔍}
ccl, cells, cancer, ccr, macrophages, mice, lung, mams, metastasis, tumor, cell, fig, breast, pubmed, google, scholar, doi, data, expression, monocytes, human, experiments, mouse, metastatic, independent, number, ims, injection, sem, elg, means, assessed, results, qian, foci, antibody, injected, pmc, chemokine, macrophage, isolated, cultured, article, cclccr, free, mrna, signaling, treatment, accumulation, promotes,
Topics {✒️}
genetically engineered mouse anti–mouse cd16/cd32 antibody org/cgi/content/full/jem lps-hyporesponsive c3h/hej mice cmftmr/cmfda double-positive population t-cell-mediated respiratory inflammation cc-chemokine ligand 2 cc-chemokine ligand 3 received bm transplantation pulmonary cell-mediated immunity rantes-induced chemokine cascade human monocyte-derived macrophages cmfda-labeled e0771-lg cells humanized anti-ccl2 antibody ccl2-triggered chemokine cascade ccl2-induced chemokine cascade anti-ccl3 neutralizing antibody chemokine-induced chemokine expression anti-ly6g antibodies treatments pmc beta search cd11b+cd115+ly6c+ inflammatory monocytes macrophage inflammatory protein-1α mam-mediated tumor metastasis transmigrated e0771-lg cells luciferase-expressing tumor cells density-dependent feedback mechanism pmc copyright notice cc-chemokine ligands ccl2–ccr2 axis plays anti-ccl2 antibody treatment ccl3-induced macrophage attachment monocyte-mediated defense facilitate breast-tumour metastasis vivo photon-counting device e0771-lg cancer cells e0771-lg tumor cells anti-integrin α4 antibodies injected e0771-lg cells lineage-specific growth factor ccl2–ccr2 signaling pathway tumor-bearing mouse lung monocyte isolation kit reduced relapse-free c-fms proto-oncogene chemokine ligand ccl3 anesthetized tumor-bearing mice chemokine pathways ccl2–ccr2 suppressing free ccl2 mip-1α[ccl3] acting mam-derived ccl3
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