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Title[redir]:
GLP-1(32-36)amide Pentapeptide Increases Basal Energy Expenditure and Inhibits Weight Gain in Obese Mice - PMC
Description:
The prevalence of obesity-related diabetes is increasing worldwide. Here we report the identification of a pentapeptide, GLP-1(32-36)amide (LVKGRamide), derived from the glucoincretin hormone GLP-1, that increases basal energy expenditure and ...
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Keywords {🔍}
mice, glpamide, vehicle, weeks, pentapeptide, glucose, doi, energy, pubmed, google, scholar, peptide, insulin, levels, glp, fig, increased, ucp, plasma, skeletal, muscle, hfd, weight, panel, expenditure, expression, infusions, pmc, diabetes, obese, compared, group, body, article, mass, free, fatty, myotubes, fed, week, fat, acc, total, control, hepatic, ampk, bat, min, receiving, data,
Topics {✒️}
activates camp/pka/β-catenin signaling low-molecular-weight serum proteins high-fat diet-fed mice multiple reaction monitoring-based pmc beta search rat/mouse elisa kit streptozotocin-induced diabetic mice quantitative rt-pcr assays improves β-cell mass insulin-sensitive human subjects insulin-resistant human subjects glp1-derived nonapeptide glp1 inhibited acetyl-coa carboxylase inhibits acetyl-coa carboxylase semiquantitative lc-ms assay c57bl/6j mice liquid chromatography–mass spectroscopy diet-induced obese mice transcriptional coactivator pgc-1α publisher site pdf insulin-responsive target tissues mitochondrial uncoupling-protein homologues high fat–fed mice brown adipose tissue license information pmcid reactive oxygen species basal energy expenditure c-terminal peptides glp-1 ampk-responsive pathways similar serum-free media palmitate-induced oxidative stress pentapeptide-treated mice showed amide–treated mice showed isolated mouse hepatocytes cell signaling technology obesity-related metabolic disorders improves pyruvate tolerance pentapeptide-treated obese mice acetyl-coa carboxylase incretin-based therapies peptide-treated mice began disorders remains unknown inhibit weight gain amide–treated dio mice de novo lipogenesis regular chow diet diet-induced obese fatty acid oxidation solid phase methods /kg lean mass
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- Mitochondrial uncoupling proteins—what is their physiological role?
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