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Keywords {🔍}

doi, pubmed, google, scholar, signalling, pmc, protein, article, cell, innate, assembly, free, activation, signal, domain, nature, receptor, immune, receptors, smocs, smoc, tirap, transduction, mavs, proteins, myddosome, adaptor, studies, response, death, complexes, caspase, immunity, tolllike, complex, immunol, tlr, signaling, interactions, tlrs, membrane, inflammasome, irak, filaments, higherorder, formation, nlrp, jcell, pathways, responses,

Topics {✒️}

enhance endotoxin-induced il-1β cyclic gmp-amp synthase n-terminal lipid-binding domain amino-terminal lipid-binding domain tlr-specific toll/il-1r retinoic acid-inducible gene gram-negative bacterial endotoxins higher-order signalling complexes ich1/ced3-homologous protein promiscuous lipid-binding domain tlr/il-1r signalling rip1/rip3 necrosome forms microtubule-driven spatial arrangement c-terminal transmembrane domain15 pmc beta search higher-order signalling complex nf-κb inhibitor-α toll/il-1r domain endosome-localized lipids restricts carma1/bcl10/malt1 signalosome death-inducing signalling complex carboxy-terminal tir domain46 mavs-mediated antiviral signaling form star-shaped structures nucleation-induced filamentous assembly similar membrane-targeting activities15 nucleotide-binding oligomerization domain endogenous tlr-induced myddosome forms signaling-competent filaments membrane-based smoc assembly polyubiquitin-stabilized double card putative protein–protein interactions death receptor-induced apoptosis cytosolic double-stranded dna il-1β maturation open innate immune pathways antiviral immune defense innate immune signalling signalling pathways induced myd88–irak4–irak2 complex prr-induced smoc assembly autophagy adaptor p62 higher-order oligomers higher-order assemblies innate immune system reveal important means innate immune pathways35 tlr-induced myddosome formation induce signalling responses innate immune response

Questions {❓}

• Do they represent direct protein–protein interactions?
• If signal amplification to reach a response threshold is the mechanism by which innate immune pathways are turned on, then once formed, how are SMOCs turned off to terminate signalling?

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• What's the total monthly financial gain of https://doi.org/10.1038/ni0901-835?
• How much profit is https://scholar.google.com/scholar_lookup?journal=Nature%20Immunol&title=TIRAP:%20an%20adapter%20molecule%20in%20the%20Toll%20signaling%20pathway&author=T%20Horng&author=GM%20Barton&author=R%20Medzhitov&volume=2&publication_year=2001&pages=835-841&pmid=11526399&doi=10.1038/ni0901-835& making per month?
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• https://doi.org/10.1074/jbc.M109.022392's financial summary
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• How much does https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl%20Acad.%20Sci.%20USA&title=Mitochondrial-associated%20endoplasmic%20reticulum%20membranes%20(MAM)%20form%20innate%20immune%20synapses%20and%20are%20targeted%20by%20hepatitis%20C%20virus&author=SM%20Horner&author=HM%20Liu&author=HS%20Park&author=J%20Briley&author=M%20Gale&volume=108&publication_year=2011&pages=14590-14595&pmid=21844353&doi=10.1073/pnas.1110133108& pull in?
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• Check the income stats for https://doi.org/10.1126/scisignal.2001147
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• See how much https://scholar.google.com/scholar_lookup?journal=Nature%20Immunol&title=Diverse%20intracellular%20pathogens%20activate%20type%20III%20interferon%20expression%20from%20peroxisomes&author=C%20Odendall&volume=15&publication_year=2014&pages=717-726&pmid=24952503&doi=10.1038/ni.2915& makes per month
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