
NCBI . NLM . NIH . GOV {
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Title[redir]:
EGFR-directed monoclonal antibodies in non-small cell lung cancer: how to predict efficacy? - PMC
Description:
Cetuximab improved survival when added to first-line platinum-based chemotherapy in patients with advanced non-small cell lung cancer. In order to determine those patients who will derive the greatest benefit from the addition of cetuximab, the ...
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Keywords {🔍}
cetuximab, patients, chemotherapy, egfr, survival, phase, advanced, cancer, lung, nsclc, expression, google, scholar, doi, pubmed, firstline, trial, oncol, treatment, monoclonal, benefit, flex, trials, study, iii, nonsmallcell, predictive, antibodies, cell, treated, randomized, clin, tumor, compared, kras, mutations, biomarkers, response, score, receptor, antibody, egfrdirected, clinical, high, status, tumors, bms, staining, ihc, platinumbased,
Topics {✒️}
transforming growth factor-alpha antibody-dependent cellular cytotoxicity anti-allergic pre-medication small-cell lung cancer small-cell lung cancer humanized monoclonal antibody cetuximab-related side effects egfr-directed monoclonal antibodies pmc beta search egfr-activating mutations independent egfr copy numbers longer progression-free survival advanced egfr mutation-positive kras wild-type predicts superior progression-free survival antibody receptor complexes publisher site pdf progression-free survival determined platinum-based chemotherapy regimens advanced egfr-positive nsclc page abstract introduction phase iii trials egfr-activating mutations progression-free survival egfr-targeted therapy phase iii study line platinum-based chemotherapy license information pmcid reach statistical significance phase ii study secondary efficacy endpoints egfr-directed tkis kras mutation status tyrosine kinase inhibitors egfr ihc scores egfr expression levels squamous cell carcinomas acknowledgements disclosure cetuximab-treated advanced stage targeted therapies infusion-related reactions intracellular tyrosine kinase immunohistochemical egfr expression egfr-positive advanced kras wild-type platinum-based doublets united states government rare hypersensitivity reactions adequate organ functions symptomatic peripheral neuropathy
Questions {❓}
- EGFR-directed monoclonal antibodies in non-small cell lung cancer: how to predict efficacy?
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