
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Slug contributes to cancer progression by direct regulation of ERα signaling pathway - PMC
Description:
Hormone therapy targeting estrogen receptor α (ERα) is the most effective treatment for breast cancer. However, this treatment eventually fails as the tumor develops resistance. Although reduced expression of ER-α is a known contributing factor to ...
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Keywords {🔍}
slug, cancer, erα, doi, cell, cells, expression, breast, pubmed, google, scholar, fig, mcf, cat, resistance, pmc, prostate, protein, tamoxifen, article, transcription, mcftamr, free, drug, mdamb, lines, tumor, performed, assay, usa, normal, progression, line, phenotype, emt, development, mcfa, egfr, stem, role, tissue, tma, epithelial, mesenchymal, factors, patients, carcinoma, promoter, decreased, increased,
Topics {✒️}
akt/gsk-3beta/snail signalling pathway zinc-finger transcription factor human colon-cancer-initiating cells slug-positive erα-negative finding slug-negative erα-positive finding nih/ncats ctsi ul1tr000124 tissue histologic/pathology classification erα-negative mda-mb-231 cells zinc-finger protein slug pmc beta search predicts disease-free survival oestrogen-receptor-mediated transcription pcmv6-ac-gfp vector pre-coated matrigel wells thermoscript rt-pcr system invasivenes-sand metastatic capabilities drug-resistant pluripotent cells mba-mb231/shslug clone 1 mda-mb-231 cell line mda-mb-231/shslug clones prostate cancer-related deaths mda/shslug2 cell lines mda-mb-231/shslug2 cells pmc copyright notice quantitative real-time pcr anti-mouse igg-fitc anti-rabbit igg-fitc slug-erα signaling pathway triple-negative breast cancer mcf-tamr cell line mda-mb-231 stably transfected mcf-tamr cell lines erα-negative breast cells cancer-stem-cell model serum-free media methods cell lines luciferase-based viability assay slug-negative/erα-positive slug-positive/erα-negative slug-induced cancer progression specific binding site master transcription factor histologic cellular classification nih-nimhd u54md007598 promotes tumor formation mcf-tamr showed resistance performed comparing mda/shcon mcf-tamr cells compared typically hormone-dependent estrogen receptors beta
Questions {❓}
- Do ‘basal-like’ breast cancers really exist?
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