
NCBI . NLM . NIH . GOV {
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Title[redir]:
Second-generation PLINK: rising to the challenge of larger and richer datasets - PMC
Description:
PLINK 1 is a widely used open-source C/C++ toolset for genome-wide association studies (GWAS) and research in population genetics. However, the steady accumulation of data from imputation and whole-genome sequencing studies has exposed a strong need ...
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Keywords {🔍}
plink, doi, linux, mac, win, data, bit, google, scholar, pubmed, nomem, pmc, article, table, test, algorithm, population, variants, free, likelihoods, exact, format, file, analysis, matrix, software, variant, tables, association, ibs, allele, synth, linkage, genomic, genotype, reference, machine, dataset, information, alleles, number, set, hardyweinberg, fishers, datasets, tests, operations, additional, pairs, haplotype,
Topics {✒️}
write-var-ranges simplifies splitting early-termination snp-hwe algorithm /writings/diary/archive/2011/11/02/faster_popcount_update early-termination snp-hwe genome-wide case-control studies major/minor-allele based design multiple-testing adjusted p-values modern l2/l3 caches high-density snp genotyping graphics processing units genome-wide interaction analysis variance-normalizing distance function reduce disk-caching variance genome-wide association studies pmc beta search high-end computing resources detecting gene-gene interactions distance/relationship partial sums fast-epistasis variance correction floating point adds/multiplies likelihood-based qtdt enjoyed 𝑦 𝑣 𝑖 𝑦 𝑤 𝑖 additional low-level optimizations hardy-weinberg equilibrium gplv3-licensed open source improved sse2-based implementation likelihoods decay super-geometrically population-based linkage analyses ieee-754 double-precision numbers lookup table-based algorithm dot-product terms longest base-pair spans high-accuracy haplotype phasing prints mini-manual entries snp-hwe exploits hardy-weinberg assumptions hardy-weinberg proportion genomic relationship matrix primary data format snp-hwe algorithm heavy-duty operations default gene-trait mapping sequence alignment/map format [google scholar] 11 𝑣 𝑖 𝑤 𝑖 core file format oldest x86-64 processors make-grm-bin command
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- Linux32-2 nomem ∼4300 k?
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- Com/longcontest/?
- –ld-window-kb 500 chr1 Mac-2 nomem ∼2700 k?
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