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Keywords {🔍}

doi, cell, pubmed, google, scholar, tumor, ecm, cancer, pmc, article, free, cells, growth, progression, matrix, signaling, extracellular, tissue, biol, adhesion, survival, proliferation, cycle, collagen, activity, development, expression, response, breast, promotes, metastasis, activation, hallmarks, receptor, protein, cellular, factor, kinase, nature, migration, mechanical, tumors, increased, angiogenesis, patients, fak, endothelial, integrin, sci, immune,

Topics {✒️}

phosphatidylinositol 3-kinase function proto-oncogene mechanotransduction lysyl oxidase inhibitor oncogene-directed tumor–ecm interactions growth factor-dependent signaling focal adhesion kinase focal-adhesion kinase dominant rho-family gtpase enhanced post-translational modifications cyclin-dependent kinases enhancing pi3k/akt activity rat aorta model rho gtpase signaling beta4 integrin-dependent formation p75ngfr/bcl2/integrin beta4 t-cell-mediated cell death pmc beta search pro-apoptotic protein bim tgf-beta blockade improves pi3k-dependent breast tumorigenesis p27 remain high fak-p130cas complex smad phosphorylation anchorage-dependent cells detaching raf 121 adhesion-dependent cell survival cyclin d1 induction laminin-binding receptor permits nf-κb activation tgf-beta1-induced apoptosis tgf-β induces proteins anti-apoptotic molecules including inducing p130cas enabling replicative immortality p53 protein interactions epithelial-mesenchymal transition growth factor receptors tgf-β secreted ecm adhesion-induced signals require integrin-mediated adhesion suppress p53-induced apoptosis bleomycin-induced pulmonary fibrosis collagen receptor ddr1 ferm-enhanced p53 degradation bleomycin-induced lung fibrosis activating invasion stimulates erk signaling modulate vascular development hypoxia-induced lysyl oxidase cyclin d1 7

Questions {❓}

• Are the enhanced biomechanical properties of the ECM observed in tumors a causative or correlative factor to tumor development?
• At which point in a tumor cells' response to the altered ECM biochemical and biophysical properties it is most efficacious to therapeutically intervene?
• Is the influence of the ECM on tumor progression consistent through various cancer origins and subtypes?
• Mechanotransduction - a field pulling together?
• The inflammation-fibrosis link?
• What are the cellular sources inducing an altered ECM deposition and remodeling during cancer progression?

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• Income figures for https://doi.org/10.1016/j.cell.2008.09.043
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• Check the income stats for https://doi.org/10.1126/science.1171362
• https://scholar.google.com/scholar_lookup?journal=Science&title=Inhibition%20of%20Hedgehog%20signaling%20enhances%20delivery%20of%20chemotherapy%20in%20a%20mouse%20model%20of%20pancreatic%20cancer&author=KP%20Olive&author=MA%20Jacobetz&author=CJ%20Davidson&author=A%20Gopinathan&author=D%20McIntyre&volume=324&publication_year=2009&pages=1457-1461&pmid=19460966&doi=10.1126/science.1171362&'s total income per month
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• https://doi.org/10.1038/nature12624 income
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• How much does https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Stromally%20derived%20lysyl%20oxidase%20promotes%20metastasis%20of%20transforming%20growth%20factor-beta-deficient%20mouse%20mammary%20carcinomas&author=MW%20Pickup&author=H%20Laklai&author=I%20Acerbi&author=P%20Owens&author=AE%20Gorska&volume=73&publication_year=2013&pages=5336-5346&pmid=23856251&doi=10.1158/0008-5472.CAN-13-0012& pull in monthly?
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