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sclc, cell, thz, figure, doi, cells, treatment, mice, transcription, lung, lines, gene, cancer, genes, pubmed, google, scholar, ncih, tumor, disease, pmc, article, factors, free, expression, small, neuroendocrine, msclc, transcriptional, inhibitors, viability, compared, superenhancers, identified, observed, line, glc, factor, established, data, thztreated, superenhancer, amplification, top, cdk, tumors, experimental, hsclc, nature, myc,

Topics {✒️}

serum-free hormone-supplemented medium regulate tumor-initiating capacity achaete-scute homologue essential subgroup-specific structural variation lineage-specific transcription factors unbiased high-throughput screen neuroendocrine lineage-specific factors sclc targeted therapy mts-based ckk-8 assay small-cell lung carcinoma lkb1-mutant lung cancer acetyl-lysine binding site magnetic bead bound-antibody classical sphere-forming morphology leading-edge gene set small-cell lung cancer activates rnapii-mediated transcription high-throughput drug screen high-throughput cellular screen �leading-edge gene’ sets highly lineage-defining trait pmc beta search precipitated protein-dna complexes focally amplified c-myc pan-cdk inhibitors targeting steady-state mrna levels proto-oncogenic transcription factors mit-dfci bridge grant h3k27ac chip-seq occupancy amplified lineage-specific top-5% highest-expressed genes expression ‘leading-edge genes nvp-auy922 targets hsp90 e2f-regulated gene sets thz1-cis-eto treated mice cre-lox mediated recombination leading-edge genes identified input-normalized h3k27ac signal celltiter-glo lumeniscent assay tumor-bearing rp mouse c-myc gene loci nci-h82 cell lines human pre-clinical models nci-h82 cell line super-enhancer landscape recapitulated higher-order transcriptional cdks nci-h69 cell lines master transcription factor transcription factor genes sclc pre-clinical models

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