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Title[redir]:
Ectopic MicroRNA-150-5p Transcription Sensitizes Glucocorticoid Therapy Response in MM1S Multiple Myeloma Cells but Fails to Overcome Hormone Therapy Resistance in MM1R Cells - PMC
Description:
Glucocorticoids (GCs) selectively trigger cell death in the multiple myeloma cell line MM1S which express NR3C1/Glucocorticoid Receptor (GR) protein, but fail to kill MM1R cells which lack GR protein. Given recent demonstrations of altered microRNA ...
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Keywords {๐}
cells, mirp, cell, mms, google, scholar, pubmed, doi, dex, mmr, expression, gene, levels, pmc, transfection, article, free, mrna, fig, death, treatment, data, analysis, receptor, cycle, transcription, glucocorticoid, genes, specific, multiple, effects, pathways, regulation, therapy, response, qpcr, myeloma, protein, microrna, control, micrornas, cancer, hsamir, treated, activation, responsive, target, table, proliferation, cellular,
Topics {โ๏ธ}
hsp90-targeted mirna-liposomal formulation thalidomideโdexamethasone-bortezomib based regimens mir-150-5p-specific nr3c1 networks versus lenalidomide-low-dose dexamethasone biaxin [clarithromycin]/revlimid [lenalidomide]/dexamethasone redundant mir-150-5p isomirs s100a8/a9 induces autophagy synthetic mir-150-5p mimetic glucocorticoid-induced leucine zipper b-cell neoplasm characterized synthetic mir-150-5p vesicles high bic/mir-155 expression ros-mediated cross-talk beta2-adrenergic receptor agonists ectopic mir-150-5p expression validated gc-inducible mirs ligand-dependent nuclear receptor mir-150-5p mimetic transfection long-term lenalidomide therapy mir-150-5p specific mrna pmc beta search anti-apoptotic translational isoform osteoblastic mc3t3-e1 cells mir-150-5p responsive mrnas mir-150-5p responsive activation mir-150-5p specific antagomir mir-150-5p-specific antagomir express nr3c1/glucocorticoid receptor springer science+business media mll-fusion/myc/lin-28 combining mir-150-5p transfection increased mir-150-5p levels synthetic mir-150-5p transfection dexamethasone-induced cell death genome-wide transcription profiles z-score cell death mir-150-5p selective decrease anti-apoptotic gr isoforms supporting information files ectopic mir-150-5p transfection suppressing pi3k/akt signaling activation z-score tp53 lenalidomide-low-dose dexamethasone glucocorticoid receptor-mediated apoptosis mir-150-5p transcription levels p-glycoprotein mediated regulation data availability statement dependent post-transcriptional regulation 02 hsa-mir-146b-5p reverse mir-150-5p effects
Questions {โ}
- De Bosscher K, Beck IM, Haegeman G (2010) Classic glucocorticoids versus non-steroidal glucocorticoid receptor modulators: survival of the fittest regulator of the immune system?
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- https://doi.org/10.4161/cbt.26607's financial summary
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- Discover the revenue of https://scholar.google.com/scholar_lookup?journal=Int%20J%20Cancer&title=Growth%20inhibition%20of%20colon%20cancer%20cells%20by%20polyisoprenylated%20benzophenones%20is%20associated%20with%20induction%20of%20the%20endoplasmic%20reticulum%20response&author=P%20Protiva&author=ME%20Hopkins&author=S%20Baggett&author=H%20Yang&author=M%20Lipkin&volume=123&publication_year=2008&pages=687-694&pmid=18470880&doi=10.1002/ijc.23515&
- Revenue of https://doi.org/10.1159/000342502
- How much does https://scholar.google.com/scholar_lookup?journal=Endocr%20Dev&title=Exploring%20the%20molecular%20mechanisms%20of%20glucocorticoid%20receptor%20action%20from%20sensitivity%20to%20resistance&author=S%20Ramamoorthy&author=JA%20Cidlowski&volume=24&publication_year=2013&pages=41-56&pmid=23392094&doi=10.1159/000342502& bring in each month?
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- What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=J%20Allergy%20Clin%20Immunol&title=Corticosteroid%20resistance%20in%20patients%20with%20asthma%20and%20chronic%20obstructive%20pulmonary%20disease&author=PJ%20Barnes&volume=131&publication_year=2013&pages=636-645&pmid=23360759&doi=10.1016/j.jaci.2012.12.1564&?
- How much does https://doi.org/10.1016/j.mce.2008.10.001 gross monthly?
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- https://scholar.google.com/scholar_lookup?journal=PLoS%20One&title=MicroRNA%20profiling%20in%20mucosal%20biopsies%20of%20eosinophilic%20esophagitis%20patients%20pre%20and%20post%20treatment%20with%20steroids%20and%20relationship%20with%20mRNA%20targets&author=S%20Lu&author=VA%20Mukkada&author=S%20Mangray&author=K%20Cleveland&author=N%20Shillingford&volume=7&publication_year=2012&pages=e40676&pmid=22815788&doi=10.1371/journal.pone.0040676&'s financial summary
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- How much does https://scholar.google.com/scholar_lookup?journal=Oncogene&title=The%20role%20of%20miR-150%20in%20normal%20and%20malignant%20hematopoiesis&author=Y%20He&author=X%20Jiang&author=J%20Chen&publication_year=2013&pmid=23955084&doi=10.1038/onc.2013.346& bring in each month?
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- How much does https://scholar.google.com/scholar_lookup?journal=Cell&title=MiR-150%20controls%20B%20cell%20differentiation%20by%20targeting%20the%20transcription%20factor%20c-Myb&author=C%20Xiao&author=DP%20Calado&author=G%20Galler&author=TH%20Thai&author=HC%20Patterson&volume=131&publication_year=2007&pages=146-159&pmid=17923094&doi=10.1016/j.cell.2007.07.021& rake in every month?
- https://scholar.google.com/scholar_lookup?journal=Oncogene&title=The%20role%20of%20miR-150%20in%20normal%20and%20malignant%20hematopoiesis&author=Y%20He&author=X%20Jiang&author=J%20Chen&volume=33&publication_year=2014&pages=3887-3893&pmid=23955084&doi=10.1038/onc.2013.346&'s revenue stream
- https://doi.org/10.4049/jimmunol.1001794's revenue stream
- Explore the financials of https://scholar.google.com/scholar_lookup?journal=J%20Immunol&title=The%20human%20glucocorticoid%20receptor%20as%20an%20RNA-binding%20protein:%20global%20analysis%20of%20glucocorticoid%20receptor-associated%20transcripts%20and%20identification%20of%20a%20target%20RNA%20motif&author=FT%20Ishmael&author=X%20Fang&author=KR%20Houser&author=K%20Pearce&author=K%20Abdelmohsen&volume=186&publication_year=2011&pages=1189-1198&pmid=21148795&doi=10.4049/jimmunol.1001794&
- How much money does https://doi.org/10.33549/physiolres.932410 generate?
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- Discover the revenue of https://scholar.google.com/scholar_lookup?journal=J%20Biol%20Chem&title=Reduced%20miR-124a%20and%20miR-150%20levels%20are%20associated%20with%20increased%20pro-inflammatory%20mediator%20expression%20in%20KLF2-deficient%20macrophages&author=P%20Manoharan&author=JE%20Basford&author=R%20Pilcher-Roberts&author=J%20Neumann&author=DY%20Hui&publication_year=2014&pmid=25248747&doi=10.1074/jbc.M114.579763&
- How much cash flow does https://doi.org/10.1002/path.2333 have monthly?
- How much money does https://scholar.google.com/scholar_lookup?journal=J%20Pathol&title=miRNA%20analysis%20in%20B-cell%20chronic%20lymphocytic%20leukaemia:%20proliferation%20centres%20characterized%20by%20low%20miR-150%20and%20high%20BIC/miR-155%20expression&author=M%20Wang&author=LP%20Tan&author=MK%20Dijkstra&author=K%20van%20Lom&author=JL%20Robertus&volume=215&publication_year=2008&pages=13-20&pmid=18348159&doi=10.1002/path.2333& make?
- What's https://doi.org/10.1074/jbc.M113.489302's gross income?
- How much revenue does https://scholar.google.com/scholar_lookup?journal=J%20Biol%20Chem&title=Microvesicle-mediated%20transfer%20of%20microRNA-150%20from%20monocytes%20to%20endothelial%20cells%20promotes%20angiogenesis&author=J%20Li&author=Y%20Zhang&author=Y%20Liu&author=X%20Dai&author=W%20Li&volume=288&publication_year=2013&pages=23586-23596&pmid=23766514&doi=10.1074/jbc.M113.489302& produce monthly?
- How much profit is https://doi.org/10.1073/pnas.1311145110 making per month?
- What's the monthly money flow for https://scholar.google.com/scholar_lookup?journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&title=Synthesis%20and%20delivery%20of%20short,%20noncoding%20RNA%20by%20B%20lymphocytes&author=G%20Almanza&author=V%20Anufreichik&author=JJ%20Rodvold&author=KT%20Chiu&author=A%20DeLaney&volume=110&publication_year=2013&pages=20182-20187&pmid=24277816&doi=10.1073/pnas.1311145110&?
- How much does https://github.com/ncbi generate monthly?
- What's https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323's gross income?
- https://www.nlm.nih.gov/web_policies.html income
- Discover the revenue of https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office
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