NCBI . NLM . NIH . GOV {
}
We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC4243043/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC4243043/. The analysis below is for the second page.
Title[redir]:
CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer - PMC
Description:
The MYC oncoproteins are thought to stimulate tumor cell growth and proliferation through amplification of gene transcription, a mechanism that has thwarted most efforts to inhibit MYC function as potential cancer therapy. Using a novel covalent ...
Title[redir]:
CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer - PMC
Description:
The MYC oncoproteins are thought to stimulate tumor cell growth and proliferation through amplification of gene transcription, a mechanism that has thwarted most efforts to inhibit MYC function as potential cancer therapy. Using a novel covalent ...
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Keywords {🔍}
cells, thz, mycn, mycnamplified, cell, doi, figure, expression, cdk, transcriptional, genes, analysis, gene, treated, nonamplified, shsyy, pubmed, google, scholar, kelly, transcription, myc, pmc, treatment, amplification, article, human, pol, free, tumor, dmso, hkac, inhibition, rna, effects, binding, levels, ses, control, cycle, data, western, cancer, cdks, phosphorylation, figures, global, imr, tumors, enhancers,
Topics {✒️}
pmc beta search t-type cyclin/cdk9 complexes short-read aligner bowtie mycn-nonamplified sh-sy5y cells myc/mycn-deregulated cells led mycn-overexpressing cells sensitizes build version grch37/hg19 dana-farber cancer institute sh-sy5y cells expressing mycn-amplified cells expressing extended experimental procedures animals remained free dna-free™ dnase mycn-overexpressing nb cells human mycn-amplified nb z-scores calculated visualize chip-seq tracks mycn-amplified cells coincided endogenous mycn-amplified cells high mycn-expressing cells mycn-overexpressing cells correlated mycn-amplified cell lines anti-cancer drug flavopiridol mycn-driven nb cells myc-driven tumor cells mediator establish super-enhancers myc-induced transgenic tumors mycn-amplified tumor models mycn-amplified nb cells mycn-amplified tumor cells mycn-amplified cells exposed mycn-dependent transcriptional amplification mycn-driven transcriptional amplification facilitate high-level expression cyclin-dependent kinase control chip-seq data thresholds nih-3t3 cells treated functionally replace c-myc translocated c-myc oncogene cdk-activating kinase subunits sh-sy5y cells treated mycn-amplified cells treated thz1 10mg/kg iv mycn-induced transcriptional amplification mycn-amplified tumor samples myc-induced transcriptional amplification sh-sy5y cells led mycn shrna-depleted cells mycn-amplified cells led carboxy-terminal domain
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