NCBI . NLM . NIH . GOV {
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Title[redir]:
Ipilimumab in patients with melanoma and autoimmune disease - PMC
Description:
Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4), an immune-checkpoint receptor and regulator of T-cell activation, has become an important therapeutic target for immunotherapy in cancer and autoimmune diseases. To date, clinical trials involving cancer ...
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Keywords {🔍}
ipilimumab, melanoma, doi, patients, autoimmune, patient, treatment, clinical, multiple, pubmed, google, scholar, pmc, cancer, disease, underlying, ctla, nlm, diseases, showed, metastatic, article, sclerosis, biopsy, lymph, node, scan, ncbi, search, events, case, daily, subcutaneous, free, wolchok, immunotherapy, immunotherapies, active, received, rheumatoid, arthritis, treated, criteria, initial, revealed, due, nodules, response, advanced, information,
Topics {✒️}
immune-checkpoint inhibitors anti-ctla-4 immune-related adverse events competing interests case presentation 1 case presentation 2 profound anti-tumor effect pmc beta search seronegative rheumatoid arthritis license information pmcid pmc copyright notice ongoing immune suppression temozolomide 75 mg/m2 daily immune-checkpoint receptor separate lymph node molecular analysis revealed t-cell activation left knee aspiration irae profile scan showed evidence rheumatoid arthritis clinical trial involving increased clinical contact publisher site pdf multiple clinical events active multiple sclerosis fully human antibody limited clinical experience low-dose prednisone worsening symptoms related underlying autoimmune conditions underlying autoimmune disease molecular analysis showed multiple joint effusions gamma secretase inhibitor conclusions programmed cell death-1 acknowledgements references 1 anti-ctla-4 treatment underlying autoimmune diseases progressive subcutaneous lesions low-dose corticosteroids extended-dose temozolomide underlying autoimmune disorder optimally treat ra united states government united states food inflammatory side effects maintaining immunologic homeostasis including murine models
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