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Title[redir]:
Spleen Tyrosine Kinase Inhibition Attenuates Autoantibody Production and Reverses Experimental Autoimmune GN - PMC
Description:
Spleen tyrosine kinase (SYK) has an important role in immunoreceptor signaling, and SYK inhibition has accordingly attenuated immune-mediated injury in several in vivo models. However, the effect of SYK inhibition on autoantibody production remains ...
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Keywords {🔍}
syk, day, animals, treatment, cells, disease, fostamatinib, inhibition, figure, doi, pubmed, google, scholar, production, glomerular, reduction, glomeruli, psyk, experimental, rat, fostamatinibtreated, antibody, antigbm, kinase, autoantibody, pmc, autoimmune, renal, clinical, effects, tyrosine, effect, model, data, article, cell, responses, levels, injury, expression, induction, macrophages, period, inhibitor, bcell, vivo, established, lung, eag, tsyk,
Topics {✒️}
mrl/lpr lupus-prone mice14 fitc-labeled anti-rat igg biotin-streptavidin–based secondary system antigen-specific autoantibody-producing splenocytes antibody-dependent fcr-mediated responses anti-collagen antibody-induced arthritis owns stocks/stock options anti–double-stranded dna org/lookup/suppl/doi cytometric bead array validated b-cell markers tnf-alpha reduces inflammation deposited anti-gbm antibody pmc beta search heat-aggregated rat igg26 anti-gbm antibody levels broncho-alveolar lavage fluid attenuated immune-mediated injury anti-insulin antibody levels spleen tyrosine kinase enumerate antigen-specific splenic l929-conditioned culture media clinical anti-gbm disease deposited anti-gbm antibodies late-phase clinical trials antibody-mediated effector functions mediating fcr-induced responses experimental anti-gbm disease syk-dependent signaling pathways cd8-positive cell infiltration b-cell elispot assay b-cell elispot assays pmc copyright notice research project grant supplementary materials included rat p-syk tyr323 glomerular macrophage infiltration macrophage infiltration proceeded blocked b-cell development rodent p-syk try323 18-day treatment-free period short-term fostamatinib treatment human p-syk tyr535/536 human p-syk tyr525/526 supplemental material online p-syk colocalized strongly orally bioavailable prodrug rat spleen tissue nonreceptor tyrosine kinase concise methods
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- Mayadas TN, Rosetti F, Ernandez T, Sethi S: Neutrophils: Game changers in glomerulonephritis?
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- https://github.com/ncbi's total income per month
- https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323's financial summary
- How much does https://www.nlm.nih.gov/web_policies.html gross monthly?
- What's the total monthly financial gain of https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office?
- What's the monthly money flow for https://www.hhs.gov/vulnerability-disclosure-policy/index.html?
- What's the monthly income of https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Ajournal?
- Explore the financials of https://www.nlm.nih.gov/accessibility.html
- https://www.nlm.nih.gov/careers/careers.html's revenue stream
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- What's the income generated by https://www.nih.gov/ each month?
- How much does https://www.hhs.gov/ bring in each month?
- https://www.usa.gov/ income
Analytics and Tracking {📊}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {📚}
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi