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Title[redir]:
Dual Activation of the Bile Acid Nuclear Receptor FXR and G-Protein-Coupled Receptor TGR5 Protects Mice against Atherosclerosis - PMC
Description:
Bile acid signaling is a critical regulator of glucose and energy metabolism, mainly through the nuclear receptor FXR and the G protein-coupled receptor TGR. The purpose of the present study was to investigate whether dual activation of FXR and TGR5 ...
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Keywords {🔍}
int, mice, tgr, apoe, fxr, acid, treated, levels, activation, doi, bile, pubmed, nfκb, google, scholar, reduced, ldlr, analysis, receptor, macrophages, production, data, fig, cytokine, pmc, treatment, serum, atherosclerosis, article, cholesterol, acids, pka, effects, inflammation, activity, free, study, cells, expression, dual, atherosclerotic, binding, hepatic, aortas, lipid, inhibits, effect, formation, showed, weight,
Topics {✒️}
newman-keuls post-hoc test liquid-chromatography mass spectrometry lps-induced tnf-alpha production protein-coupled receptor tgr protein-coupled receptor responsive rp-8-br-camps completely blocked pka inhibitor rp-8-br-camps transhepatic cholesterol efflux data availability statement classical nf-κb complex supporting information files pmc beta search active nf-κb levels atp-binding cassette subfamily elicit anti-atherogenic effects stearoyl-coa desaturase 1 nf-κb p65/50 complex elicit anti-inflammatory effects lps-induced cytokine production aortic nf-κb activity nf-κb binding activity nf-κb pathway contributes atherosclerotic plaque formation camp-pka-mediated inhibition reduced serum cholesterol expressed high levels adenosine-protein kinase american heart association camp-pka dependent mechanism receptor-mediated hypocholesterolemia high sensitive analysis license information pmcid lc-ms/ms nuclear receptor fxr/bar tauro-conjugated cdca levels tgr5-pka-dependent mechanism serum total cholesterol rp-8-br-camps significantly lower levels camp-pka pathway activated dna-binding results serum cholic acid data availability statements active nf-κb publisher site pdf atp binding site cholic acid deficiency hepatic cholesterol esters white fat weight bile acids including
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