
NCBI . NLM . NIH . GOV {
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Title[redir]:
tRNA Modifying Enzymes, NSUN2 and METTL1, Determine Sensitivity to 5-Fluorouracil in HeLa Cells - PMC
Description:
Nonessential tRNA modifications by methyltransferases are evolutionarily conserved and have been reported to stabilize mature tRNA molecules and prevent rapid tRNA decay (RTD). The tRNA modifying enzymes, NSUN2 and METTL1, are mammalian orthologs of ...
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Keywords {π}
cells, nsun, mettl, knockdown, trna, lane, cell, control, cancer, google, scholar, vectortransfected, pubmed, figure, doi, growth, hela, trm, expression, significant, yeast, heat, data, pmc, double, stress, open, tif, effects, assay, article, xpressnsun, scrambled, human, overexpression, analysis, free, rna, clones, sensitivity, empty, survival, circle, vitro, fluorouracil, agar, additional, xpresstagged, proteins, compared,
Topics {βοΈ}
producing dephosphorylation-mimic mettl1-s27a producing phosphorylation-mimic mettl1-s27e xpress-tagged dephosphorylation-mimic mettl1 xpress-tagged phosphorylation-mimic mettl1 utr-targeting shrna-mediated nsun2 h-rasg12v-induced cell transformation xpress-mettl-1-overexpressing cells compared nop2/sun domain family nol1/nop2/sun domain laemmli sds-sample buffer autosomal-recessive intellectual disability microtubule-stabilizing mitotic inhibitor ras-mediated cell transformation pmc beta search interdisciplinary/priority research h-25 xpress-tagged nsun2-s139a xpress-tagged nsun2-s139e control vector-transfected cells anti-Ξ±-tubulin antibodies xpress-mettl-1-overexpressing cells dose-dependent cell survival mediates myc-induced proliferation compare interferon alfa-2a trm4-mediated trna modification 5-fu-induced cell death anti-Ξ±-tubulin antibody bio-rad protein assay overexpressed xpress-tagged proteins xpress-mettl1-overexpressing cells time-dependent cell survival heat stress-induced cytotoxicity xpress-nsun2-overexpressing cells trna-modifying enzymes nsun2 5-fu-induced trna damage dephosphorylation-mimic forms anchorage-independent colonies grown heat-treated hela cells dephosphorylation-mimic nsun2 5-fu-induced trna destabilization rna gel electrophoresis mettl1 conferred protection mettl1-dependent potentiation mechanism akt/protein kinase bΞ± potentiate ras-induced phosphorylation-mimic forms double nsun2/mettl1 knockdowns nsun2-mediated cytosine-5 methylation license information pmcid supplementary materials included scrambled shrna control
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- (2012) Combinational therapy: new hope for pancreatic cancer?
- Ruggero D, Pandolfi PP (2003) Does the ribosome translate cancer?
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- https://scholar.google.com/scholar_lookup?journal=DNA%20Cell%20Biol&title=Transfer%20RNA%20methytransferases%20and%20their%20corresponding%20modifications%20in%20budding%20yeast%20and%20humans:%20activities,%20predications,%20and%20potential%20roles%20in%20human%20health&author=WL%20Towns&author=TJ%20Begley&volume=31&publication_year=2012&pages=434-454&pmid=22191691&doi=10.1089/dna.2011.1437&'s revenue stream
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- https://doi.org/10.1038/359333a0's revenue stream
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- https://scholar.google.com/scholar_lookup?journal=Adv%20Cancer%20Res&title=Atypical%20transfer%20RNA's%20and%20their%20origin%20in%20neoplastic%20cells&author=E%20Borek&author=SJ%20Kerr&volume=15&publication_year=1972&pages=163-190&pmid=4553230&doi=10.1016/s0065-230x(08)60374-7&'s financial summary
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