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Keywords {🔍}

dipg, patients, gbm, doi, grade, histology, mutations, tumour, diffuse, kmh, tumours, clinical, survival, pubmed, mutation, google, scholar, leptomeningeal, cases, histone, diagnosis, histologic, autopsy, pontine, spread, pmc, features, material, intrinsic, brainstem, gliomas, years, status, pnet, found, analysis, article, molecular, wildtype, based, astrocytoma, including, biopsy, dissemination, glioma, data, acvr, fig, astrocytomas, supplementary,

Topics {✒️}

wild-type low-grade astrocytomas high-grade tumours wild-type pre-treatment biopsy/surgical specimens pvt1/myc locus gains pmc beta search cell-cycle regulatory genes receptor tyrosine kinases target lower-grade areas grade ii–iv astrocytomas grade ii-iv astrocytomas high-grade astrocytic tumours cell biology/editorial board brain tumour-related death grade iii–iv astrocytomas surgical pre-treatment material high-frequency heterozygous mutation matched biopsy/autopsy specimens publisher site pdf high-grade gliomas chromatin remodelling genes diffuse pontine tumour lower-grade histology carrying diffuse intraparenchymal infiltration george washington university recent biopsy-based studies high-grade astrocytomas infiltrative tumours exhibit electronic supplementary material brain stem gliomas diffuse brainstem glioma testing h3-mutation status h3 survived longer paediatric brainstem gliomas pre-treatment specimens deep white matter low proliferative index biologically distinct subgroups k27m-h3 mutant cases potential therapeutic targets grade ii astrocytomas infiltrative astrocytic tumour license information pmcid sanger fluorescence sequencing grade ii astrocytoma pontine gliomas haematoxylin ii kit genes frequently affected pdgfra gains/amplifications low-grade lesions copy number alterations

Questions {❓}

• Diffuse intrinsic pontine glioma (DIPG): time to biopsy again?

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