
NCBI . NLM . NIH . GOV {
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Title[redir]:
Clonal Evolution in Breast Cancer Revealed by Single Nucleus Genome Sequencing - PMC
Description:
Sequencing studies of breast tumor cohorts have identified many prevalent mutations, but provide limited insight into the genomic diversity within tumors. Here, we developed a whole-genome and exome single cell sequencing approach called Nuc-Seq ...
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Keywords {🔍}
doi, single, mutations, tumor, data, cells, cell, sequencing, cancer, scholar, google, pmc, pubmed, article, breast, fig, free, mutation, nature, nuclei, number, tnbc, copy, detected, population, clonal, coverage, subclonal, evolution, exome, rate, performed, frequencies, extended, rates, pii, genome, methods, normal, supplementary, identified, method, cancers, bulk, nonsynonymous, singlemolecule, profiles, open, skbr, genomic,
Topics {✒️}
targeted single-molecule deep-sequencing targeted single-molecule sequencing extracellular matrix-receptor signaling alice-reynolds kleberg foundation targeted ultra-deep sequencing jak2-negative myeloproliferative neoplasm single-strand consensus sequences single-molecule coverage depth generate single-molecule data pmc beta search single sk-br-3 cells triple-negative ductal carcinoma single-cell exome sequencing limited isothermal time-frame triple-negative breast cancers perform multiple-displacement-amplification age-dependent growth rate sk-br-3 population sample resolve genome-wide mutations performed single-nucleus-sequencing [google scholar] 21 [google scholar] 26 single-nuclei exome sequencing flow-sorting cell counts multi-dimensional scaling plot tnbc multi-dimensional scaling copy number profiles er single-nuclei exome triple-negative tumor cells targeted deep-sequencing copy number profiling achieve high-coverage data false positive rate detected single-nucleotide-variants copy number aberrations copy-number variations estrogen-receptor positive nuc-seq method multi-dimensional scaling copy number data sk-br-3 cells single cell exome allelic dropout rate single cell sequencing single-cell sequencing primary breast cancer copy number detection applied nuc-seq single cell genome error rates reported
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