
NCBI . NLM . NIH . GOV {
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Title[redir]:
A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors - PMC
Description:
Most melanomas harbor oncogenic BRAFV600 mutations, which constitutively activate the MAP kinase (MAPK) pathway. Although MAPK pathway inhibitors show clinical benefit in BRAFV600-mutant melanoma, it remains incompletely understood why 10-20% of ...
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Keywords {🔍}
mitf, resistance, doi, mapk, pathway, expression, melanoma, fig, cell, lines, inhibition, axl, transcriptional, state, inhibitors, pubmed, google, scholar, activity, nfκb, brafvmutant, pmc, supplementary, resistant, mitflownfκbhigh, article, melanomas, raf, cells, cancer, sensitivity, mek, intrinsic, nature, free, levels, plx, erk, inhibitor, gene, brafve, states, sensitive, activation, acquired, treatment, melanocytes, distinction, signaling, drug,
Topics {✒️}
mitf-low/nf-κb-high short-term cultures mitf-low/nf-κb-high brafv600-mutant melanomas mitf-low/nf-κb-high cell state mitf-low/nf-κb-high group relative mitf-low/nf-κb-high transcriptional state mitf-high/nf-κb-low transcriptional state mitf-low/nf-κb-high transcriptional phenotype mitf-low/nf-κb-high state prior mitf-high/nf-κb-low cellular states mitf-low/nf-κb-high subgroup mitf-high/nf-κb-low group mitf-high/nf-κb-low state mitf-high/nf-κb low state mitf-low/nf-κb-high state mitf-high/nf-κb-low melanomas mitf-low/nf-κb-high melanomas mitf-low/nf-κb-high phenotype mitf-low/nf-κb-high states mitf-high/nf-κb-low mitf-low/nf-κb-high nf-κb-high cell state goat anti-mouse igg-hrp nf-κb-high transcriptional state nf-κb-high cellular state nf-κb-high cell lines nf-κb-high resistant state nf-κb-driven transcriptional signatures nf-κb transcription factor lentiviral vectors plx304-blast-v5 nf-κb-high state melanoma short-term cultures sk-mel-5-trpm1-luciferase cells resistant short-term cultures mitf/nf-κb class distinction nf-κb-high classes sensitive short-term cultures high nf-κb activity nf-κb transcriptional profiles nf-κb transcriptional state mitf-low resistant state growth-factor-driven resistance mitf-high cell lines nf-κb expression signatures nf-κb activation appeared short-term cultures mitf-negative/axl-positive classes nf-κb-dependent fashion nf-κb agonist tnfα raf/mek/erk signaling cascade nf-κb pathway activity
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