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Title[redir]:
Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV–infected rhesus macaques - PMC
Description:
The Middle East respiratory syndrome coronavirus (MERS-CoV) has killed ∼50% of individuals known to be infected, making understanding its mechanisms of transmission and pathogenesis and identifying candidate treatments a high priority. Heinz ...
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Keywords {🔍}
doi, animals, untreated, treated, lung, pubmed, google, scholar, infection, treatment, supplementary, pmc, merscov, fig, article, ribavirin, free, ifnαb, data, rhesus, macaques, respiratory, viral, clinical, samples, analysis, cell, expression, coronavirus, severe, pneumonia, tissues, syndrome, infected, showed, tissue, blood, hedgehog, acute, group, merscovinfected, human, gene, lungs, table, pulmonary, nlm, med, middle, levels,
Topics {✒️}
transforming growth factor-α granulocyte-macrophage colony–stimulating factor quantitative real-time rt-pcr competing financial interests granulocyte colony–stimulating factor accession number gse47957 methods biosafety statement pmc beta search tumor necrosis factor-α mers-cov–infected rhesus macaques accession codes board-certified veterinarian interpreted author contributions specific anti-cov immunoreactivity reducing mers-cov replication sonic hedgehog pathways decomposition–coupled multidimensional scaling main mers-cov macrophage inflammatory protein-1α high case-fatality rate gene expression patterns gene expression dynamics distinct gene expression beta coronavirus replication mers-cov–infected group data availability statements hyperoxia-induced injury hedgehog signaling pathway log10 ratio expression bio-plex 200 instrument differentially expressed genes tgf-β tissue-specific host response severe respiratory illness license information pmcid animals received ifn-α2b pulmonary vasculature induced cell proliferation publisher site pdf sonic hedgehog il-1 receptor antagonist standard operating procedures pulmonary capillary network idiopathic pulmonary fibrosis ifn-γ levels compared supplementary materials included untreated controls respiratory morphogenesis half-full circle transient clinical disease2
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