
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study - PMC
Description:
Drug treatments for patients with high-risk myelodysplastic syndromes provide no survival advantage. In this trial, we aimed to assess the effect of azacitidine on overall survival compared with the three commonest conventional care regimens. In a ...
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Keywords {🔍}
azacitidine, patients, care, group, treatment, myelodysplastic, doi, conventional, survival, chemotherapy, syndromes, intensive, google, scholar, months, cytarabine, study, pubmed, lowdose, supportive, hospital, myeloid, acute, celgene, compared, median, analysis, investigator, international, leukaemia, syndrome, days, preselection, trial, number, higherrisk, time, university, table, transplantation, data, received, iqr, leukemia, improvement, treatments, scoring, system, years, results,
Topics {✒️}
previous red-blood-cell transfusions higher-risk myelo-dysplastic syndromes white-blood-cell count lower allogeneic stem-cell transplantation red-blood-cell transfusions granulocyte-colony-stimulating factor gerorg-august-universitat gottingen dna methyl-transferase inhibitor brien-fleming monitoring boundary adequate bone-marrow sample bone-marrow stem-cells low-dose cytosine arabinoside license information pmcid stratified log-rank tests high-risk myelodysplastic syndromes international scoring system fab=french–american–british high-risk myelodysplastic syndrome consensus-based practice guidelines pmc beta search bone-marrow blast percentage higher-risk myelodysplastic syndromes aml=acute myeloid leukaemia higher-risk myelodysplastic syndrome heinrich-heine university dusseldorf phase-iii intergroup study cmmol=chronic myelomonocytic leukaemia kaplan-meier survival curves 5-azacytidine-treated myeloid cells s-ham induction chemotherapy receiving low-dose cytarabine greater bone-marrow blasts ccr=conventional care regimen ecog performance status previous platelet transfusions advanced myelodysplastic syndrome french–american–british acute myeloid leukaemia high-risk scores high-risk karyotypes publisher site pdf dna-methyltransferase inhibitors international working group safety analyses included acute myeloid leukemia final edited form chronic myelomonocytic leukaemia3 intravenous antimicrobials divided combined dna methyltransferase acute myeloid leukaemia19
Questions {❓}
- Is there still a role for low-dose cytosine arabinoside in de novo acute myeloid leukemia in the elderly?
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