
NCBI . NLM . NIH . GOV {
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Title[redir]:
A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response - PMC
Description:
Peroxisome proliferator-activated receptor γ (PPAR-γ), a member of the nuclear hormone receptor superfamily originally shown to play a critical role in adipocyte differentiation and glucose homeostasis, has recently been implicated as a regulator of ...
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Keywords {🔍}
doi, pparγ, pubmed, google, scholar, cells, ligands, expression, cell, colonic, activation, intestinal, dpgj, gene, caco, colitis, inflammatory, colon, figure, inflammation, nfκb, dss, pmc, treated, shown, mice, brl, treatment, response, receptor, promoter, nuclear, disease, model, ilβ, effect, article, cancer, immune, proteins, stimulation, days, inhibit, epithelial, ibd, usa, free, peroxisome, epithelium, studies,
Topics {✒️}
peroxisome proliferator-activated receptor-γ peroxisome proliferator-activated receptors inducible nitric-oxide synthase enteric-coated fish-oil preparation ppar-γ–regulated reporter plasmid affinity-purified iκb-α antibody ligand-bound ppar-γ differently affinity-purified polyclonal antibody enables nf-κb/rel proteins similar cis-acting elements acyl-coa oxidase gene lipid-activated transcription factor human sucrase-isomaltase gene double-stranded oligonucleotide spanning rel/nf-κb/iκb family intestine-specific transcriptional elements double-stranded oligonucleotides spanning nonsteroidal anti-inflammatory drugs azoxymethane-induced colon carcinogenesis il-1β–stimulated caco-2 cells ppar-γ ligands interfere dominant negative n-cadherin pmc beta search c57bl/6j-apcmin/+ mice ppar-γ ligands represent cellular retinol-binding protein nf-κb controls expression nuclear factor-κb/rel pmc copyright notice prostanoids including 15-deoxy-δ12 enhance colon polyp iκb-α western blot ppar-γ–independent pathway methods cell culture potent anti-inflammatory agents reporter gene regulated iκb-α–dependent pathway tzd ppar-γ ligands nf-κb/rel factors dextran sulfate model nf-κb binding noted comprehensive functional measures iκb-α–dependent mechanism immune response–induced degradation ppar-γ antibody tumor necrosis factor signal-induced phosphorylation sucrase-isomaltase gene il-8 gene expression attenuate intestinal inflammation
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