
NCBI . NLM . NIH . GOV {
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Title[redir]:
JAK2/STAT5/Bcl-xL signalling is essential for erythropoietin-mediated protection against apoptosis induced in PC12 cells by the amyloid β−peptide Aβ25–35 - PMC
Description:
Erythropoietin (EPO) exerts neuroprotective actions in the CNS, including protection against apoptosis induced by the amyloid β−peptide Aβ25–35. However, it remains unclear which signalling pathway activated by EPO is involved in this ...
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Keywords {🔍}
epo, cells, doi, stat, jak, pubmed, google, scholar, cell, phosphorylation, erk, activation, pathway, figure, apoptosis, bclxl, erythropoietin, signalling, receptor, inhibitor, effects, expression, pathways, caspase, effect, western, increased, nuclear, aβinduced, protein, exposed, control, blot, versus, pmc, induced, amyloid, min, treated, levels, jakstat, experiments, treatment, viability, role, neurotoxicity, protective, data, protection, results,
Topics {✒️}
6-tetrahydropyridine-treated c57/bl mice acridine orange–ethidium bromide anti-apoptotic protein bcl-xl epo-induced phospho-stat5 plays neuroblastoma sh-sy5y cells anti-apoptotic factor bcl-xl 5-diphenyl-2h-tetrazolium bromide pmc beta search poly-l-lysine 5-diphenyl-tetrazolium bromide assay 12672 jak2/stat5/bcl-xl signalling peptide-forming amyloid fibrils jak2/stat5/bcl-xl pathway anti-rabbit-hrp igg amyloid β−peptide aβ25–35 detectable bcl-xl protein references alexander sph amyloid-derived peptide aβ25–35 perform ao/eb staining free radical injury pi3k/akt/gsk3β pathway epo-initiated stat5 signalling pi3k/akt signalling pathway epo-induced neuroprotection varies treat aβ-induced neurotoxicity typical morphological features serum-starved pc12 cells diminished epo-enhanced phosphorylation decreased p-jak levels 5-diphenyl-tetrazolium bromide jak2/stat5 transduction pathway epo increases p-erk1/2 epo increases p-stat5 amyloid β-peptide jak2/stat5 signalling pathway bcl-xl expression induced epo increases p-jak2 publisher site pdf aβ-induced cell death pi3k/akt signaling pathway ao/eb staining assay amyloid beta protein aggregated β-amyloid aβ25–35-induced oxidative stress genes including bcl-xl jak2-specific inhibitor ag490 anti-apoptotic protein important anti-apoptotic role amyloid beta-peptide block epo-mediated protection
Questions {❓}
- Erythropoietin in the brain: can the promise to protect be fulfilled?
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