
NCBI . NLM . NIH . GOV {
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Title[redir]:
Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ - PMC
Description:
B-RafV600E inhibitors have been suggested to promote tumor regression with the help of host immunity, but this hypothesis has not been examined directly in detail. In this study, we profiled immunological changes in the tumor microenvironment and ...
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Keywords {🔍}
cells, tumor, doi, plx, melanoma, treatment, tumors, cell, mice, figure, pubmed, google, scholar, brafve, pmc, expression, antitumor, article, melanomas, immune, free, brafvepten, cancer, signaling, microenvironment, cdl, ifnγ, infiltrating, inhibitors, intratumoral, anticd, weeks, tregs, growth, journal, agonistic, tidcs, tams, myeloid, braf, immunity, effects, cdbgr, effector, macrophages, mab, days, research, accumulation, cdcdl,
Topics {✒️}
b-rafv600e/pten-driven murine model quantitative real-time rt-pcr produce hiv-1-suppressive beta-chemokines braf-activated pten-deficient melanomas plx4720-mediated anti-tumor responses plx4720-mediated anti-tumor response brafv600e/pten melanoma-bearing mice tumor-bearing brafv600e/pten mice cd45+/ cd3−/cd11b+/gr-1−/f4/80+ plx4720-induced anti-tumor responses wild type b-raf anti-fc receptor antibody agonistic anti-cd40 antibody dysfunctional myeloid-derived cells pmc beta search agonistic anti-cd40 mab quantitative real-time pcr inhibiting b-raf kinase anti-tumor responses triggered murine brafv600e/pten melanomas brafv600e inhibitor-resistant melanoma anti-tumor immune responses evoke anti-tumor immunity brafv600e/pten melanomas prompted brafv600e inhibitor-resistant melanomas 5mg/ml collagenase iv enhance anti-tumor responses tyrcreert2/brafv600e/ptenlox mice cd11b+/gr-1+surface staining b-raf kinase gene cd11b+/gr-1+ myeloid cells boost anti-tumor responses cd45+/cd11b+/f4/80+/gr-1− anti-tumor immunological factor elevate oxidative phosphorylation advanced brafv600e/pten melanomas anti-cd40 mab treatment brafv600e/pten melanoma model anti-cd3 immunohistochemical staining induced brafv600e/pten melanomas myeloid-derived suppressor cells establish anti-tumor immunity brafv600e/pten melanomas progressed improving anti-cancer therapies brafv600e/pten melanomas grew potent anti-tumor activities pd-l1 signaling pathways elevate pd-l1 expression dendritic cell-mediated activation humanized anti-cd40 antibodies
Questions {❓}
- Which drug, and when, for patients with BRAF-mutant melanoma?
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