
NCBI . NLM . NIH . GOV {
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Title[redir]:
Global Phosphoproteomics Reveals Crosstalk between Bcr-Abl and Negative Feedback Mechanisms Controlling Src Signaling - PMC
Description:
In subtypes and late stages of leukemias driven by the tyrosine kinase fusion protein Bcr-Abl, Src signaling critically contributes to the leukemic phenotype. We performed global tyrosine phosphoprofiling using quantitative mass spectrometry of ...
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Keywords {🔍}
phosphorylation, sfk, doi, csk, bcrabl, fig, tyrosine, events, google, scholar, cells, pubmed, cell, kinase, sfks, overexpression, activity, protein, proteins, src, inhibition, analysis, perturbation, signaling, lyn, response, sites, negative, pmc, activation, dasatinib, feedback, article, experiments, substrates, figure, observed, drug, results, table, free, hck, mechanisms, ptpn, shp, baf, pdf, mass, enrichment, nihmssupplementfigurespdf,
Topics {✒️}
bcr-abl-expressing ba/f3 cells bcr-abl-transformed ba/f3 cells pan-specific anti-phosphotyrosine-based purification figure s14 nihms587281-supplement-figure_s14 figure s13 nihms587281-supplement-figure_s13 figure s11 nihms587281-supplement-figure_s11 figure s6 nihms587281-supplement-figure_s6 figure s7 nihms587281-supplement-figure_s7 figure s10 nihms587281-supplement-figure_s10 figure s4 nihms587281-supplement-figure_s4 figure s2 nihms587281-supplement-figure_s2 figure s5 nihms587281-supplement-figure_s5 figure s9 nihms587281-supplement-figure_s9 figure s3 nihms587281-supplement-figure_s3 figure s8 nihms587281-supplement-figure_s8 figure s12 nihms587281-supplement-figure_s12 p210 bcr-abl ba/f3 bcr-abl ba/f3 cells bcr-abl-driven leukemia system ras/mitogen-activated protein kinase table s4 nihms587281-supplement-table_s4 table s2 nihms587281-supplement-table_s2 bcr-abl-transformed cells respond table s1 nihms587281-supplement-table_s1 table s3 nihms587281-supplement-table_s3 bcr-abl-expressing hematopoietic cells c-terminal src-homologous kinase bcr-abl-activated ras signaling dasatinib-resistant bcr-abl variant bcr-abl-positive leukemia progression ba/f3 cells transformed transformed ba/f3 cells ba/f3 bcr-abl drug-resistant bcr-abl mutants bcr-abl-positive cells involved pan-specific anti-phosphotyrosine antibodies ba/f3 lymphoid system references nihms587281-supplement-supplementary_analysis_and_references p210 ba/f3 cells bcr-abl-positive lymphoid b bcr-abl-mediated phosphorylation events rapamycin-sensitive phosphoproteome reveals imatinib-resistant subline myl bcr-abl-expressing cells protein-tyrosine phosphatase ptp-pest bcr-abl-driven leukemia bcr-abl-driven pathologies observed bcr-abl-mediated phosphorylation bcr-abl-driven leukemias bcr-abl t315a variant
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