
NCBI . NLM . NIH . GOV {
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Title[redir]:
PPARγ Negatively Regulates T Cell Activation to Prevent Follicular Helper T Cells and Germinal Center Formation - PMC
Description:
Peroxisome proliferator-activated receptor gamma (PPARγ) is a transcription factor that regulates lipid and glucose metabolism. Although studies of PPARγ ligands have demonstrated its regulatory functions in inflammation and adaptive immunity, its ...
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Keywords {🔍}
cells, pparγ, mice, cell, doi, pubmed, google, scholar, tfh, cdpparγko, figure, expression, pmc, increased, foxo, article, helper, germinal, receptor, control, free, differentiation, yearold, follicular, tcr, cre, activation, pparγdeficient, stimulation, analysis, production, anticd, autoimmune, data, sirt, role, bcl, results, shown, values, represent, sem, regulatory, centers, spleen, formation, gamma, level, foxp, weekold,
Topics {✒️}
cd4+tcrβ+cd62llowcd44highpsgl-1lowcxcr5+pd-1+ cells peroxisome proliferator-activated receptor-gamma anti-cd3/cd28-coated beads 3-day-anti-cd3/cd28 stimulated cells quantitative real-time pcr hrp-conjugated secondary antibody peroxisome proliferator-activated receptors antibody-coated magnetic beads psgl-1low gating strategy b220+gl7+cd95+ germinal center plate-bound anti-cd3 anti-mouse ifn-γ-fitc tcr-stimulated hyper-reactivity observed pmc beta search obesity-induced insulin resistance anti-double-stranded dna ligand-dependent transcription factors soluble anti-cd28 antibodies real-time pcr foxo1 caused hyper-reactivity age-matched control mice anti-cd3 antibody stimulation pathogen-free conditions chemokine receptor cxcr5 cd4-pparγko mice prompted characterize cd4-pparγko mice anti-mouse cd4-apc publisher site pdf inhibited pparγ-meditated differentiation pparγ inhibits nf-κb female wild type cd4-pparγko mice exhibited cytokines including ifn-γ license information pmcid immune system recognizes characterized cd4-pparγko mice nuclear receptor ppars negatively selected cd4+ anti-il-7rα antibodies alpha diagnostic international cd4-pparγko mice compared anti-cd28 dynabeads cxcr5+pd-1+ tfh cells tfh cells possibly cre-mediated pparγ deletion adopted orphan receptors affecting differentiation efficiency cd4-pparγko mice demonstrated purify cd4+cd62l+ naïve spontaneous autoimmune phenotypes
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