
NCBI . NLM . NIH . GOV {
}
Title[redir]:
THetA: inferring intra-tumor heterogeneity from high-throughput DNA sequencing data - PMC
Description:
Tumor samples are typically heterogeneous, containing admixture by normal, non-cancerous cells and one or more subpopulations of cancerous cells. Whole-genome sequencing of a tumor sample yields reads from this mixture, but does not directly reveal ...
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Keywords {🔍}
tumor, number, copy, doi, theta, genome, data, cancer, aberrations, sample, sequencing, purity, interval, read, normal, subpopulations, additional, google, scholar, pubmed, intervals, depth, clonal, file, chromosome, pmc, cells, subclonal, figure, mixture, analysis, article, free, algorithm, vector, reads, absolute, model, count, likelihood, methods, single, admixture, section, dna, snp, problem, cnanorm, breast, ratios,
Topics {✒️}
european genome-phenome archive read-depth/variant-allele plot read-count/variant-allele plot [google scholar] lee pmc beta search jak2-negative myeloproliferative neoplasm �� 𝑟 𝐶 high-throughput dna sequencing predict single-nucleotide mutations targeted ultra-deep sequencing paired-end sequencing data paired-end sequencing strategies allele-specific copy number single-cell exome sequencing negative log-likelihood function somatic single-nucleotide mutation investigating intra-tumor heterogeneity breakage-fusion-bridge detection high-coverage sequencing data inferring intra-tumor heterogeneity identify intra-tumor heterogeneity study intra-tumor heterogeneity references nowell pc matched tumor/metastasis samples brute-force strategy approach acute myeloid leukemia identify copy-neutral loh high-throughput sequencing virtual snp array single nucleotide variant negative log-likelihood supplementary materials included sloan research fellowship 𝑘 𝐻 𝐶 �� 𝑟 𝐶 𝜇 ^ cancer sequencing projects copy numbers directly breakage/fusion/bridge single-nucleotide mutations high amplitude amplifications 𝐶 𝑚 �� 𝐶 𝑚 snp array data maximum copy number quantitative genotyping corrected greenman cd bladder cancer reveals copy number aberrations high-resolution mapping
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