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Title[redir]:
Comparing DNA integration site clusters with scan statistics - PMC
Description:
Motivation: Gene therapy with retroviral vectors can induce adverse effects when those vectors integrate in sensitive genomic regions. Retroviral vectors are preferred that target sensitive regions less frequently, motivating the search for ...
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Keywords {🔍}
sites, windows, regions, doi, number, vector, clumps, integration, region, window, vectors, odds, false, iss, discoveries, mse, expected, google, scholar, genomic, data, critical, jurkat, avr, site, power, discovered, set, pubmed, versus, gene, clump, pmc, cutpoints, therapy, target, methods, supplementary, bases, width, comparison, background, dna, article, hiv, infection, free, discovery, genome, chromosome,
Topics {✒️}
hacein-bey-abina [google scholar] alonso pmc beta search genome-wide insertional mutagenesis [google scholar] bourgon scid-x1 gene therapy design wet-bench follow [google scholar] free dna ends genome-wide background odds hiv primary isolate genome-wide variation yield patient-specific clumps single fixed-width scan clinical gene therapy gene-corrected subjects license information pmcid human gene therapy successful gene therapy cd4+ versus jurkat pmc disclaimer vector reflect preferences avr versus mse united states government lmo2 proto-oncogene wet bench experiments spatial inhomogeneities shared finite-state automaton cold spring harb circular binary segmentation independent bernoulli events gene therapy vectors gene therapy vectors principal function returns flanking regions follow therapeutic gene transfer recursively splits data restriction enzyme msei actual experiment comparing nucleic acids res relevant restriction site candidate retroviral vector clinical trial reporting machine learning technique log likelihood criterion dna bar coding log odds ratios restriction enzyme depends subsample genomic segments annotating genomic ranges
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