
NCBI . NLM . NIH . GOV {
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Title[redir]:
Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy - PMC
Description:
Autophagy is a cellular defense response to stress conditions, such as nutrient starvation. The type III phosphatidylinositol (PtdIns) 3-kinase, whose catalytic subunit is PIK3C3/VPS34, plays a critical role in intracellular membrane trafficking and ...
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Keywords {🔍}
pikc, mtorc, autophagy, complex, mtor, atg, doi, starvation, amino, cells, complexes, kinase, acid, activity, regulation, figure, pmc, pubmed, google, scholar, atgcontaining, inhibition, vitro, free, nutrient, article, phosphorylation, lipid, treatment, cell, assay, protein, ptdinsp, response, rptor, activation, data, atgsta, ampk, atgpikc, subjected, conditions, hek, biol, role, effect, inhibits, becnpikc, rictor, mefs,
Topics {✒️}
mouse embryonic fibroblasts atg14-5s/ta enhances lc3-ii atg14-5s/ta mutant protein cells expressing atg14-5s/ta atg14-5s/ta mutant proteins baf a1 atg14-5s/ta promotes autophagy atg14-5s/ta cells compared amino acid-free medium amino-acid free dmem rb1-inducible coiled-coil 1 aa-free medium ms/ms spectra acquisition stably express atg14-wt recombinant gst-tagged atg14 ulk1-atg13-fip200 complex required ha-atg14-5s/ta mouse rptor gene pmc beta search bafilomycin a1 autophagy-specific atg14-pik3c3 complex gst-fused recombinant atg14 atg14-free pik3c3 complexes 50 μg/ml penicillin/streptomycin 5s/ta mutant atg14-5s/ta cells atg14 free becn1-pik3c3 atp-competitive mammalian target type iii phosphatidylinositol amino acid free sequesters ulk1-atg13-rb1cc1 protein a-sepharose beads beclin 1-phosphatidylinositol-3-kinase complex mechanistic target mtor-regulated phosphoproteome reveals bonferroni post-hoc test lc3-ii band normalized class iii pi pqcxih-ha-atg14-wt rptor knockdown generated rictor ko mefs autophagy-related pik3c3 complex autophagy-specific pik3c3 kinase reduced lc3-ii accumulation rptor kd mefs nutrient-dependent mtorc1 association mammalian autophagy-specific factor autophagy-specific pik3c3 activity ampkα wild-type rapamycin-insensitive companion
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