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Title[redir]:
The peroxisome proliferator-activated receptor-α (PPAR-α) agonist, AVE8134, attenuates the progression of heart failure and increases survival in rats - PMC
Description:
To investigate the efficacy of the peroxisome proliferator-activated receptor-α (PPARα) agonist, AVE8134, in cellular and experimental models of cardiac dysfunction and heart failure. In Sprague Dawley rats with permanent ligation of the left ...
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Keywords {🔍}
ave, doi, cardiac, heart, pparα, treatment, effects, rats, pubmed, google, scholar, increased, failure, plasma, enos, hypertrophy, animals, cells, myocardial, weight, protein, rosiglitazone, expression, function, fenofibrate, mgkgd, pressure, ventricular, agonist, left, human, endothelial, effect, placebo, cell, reduced, ratio, blood, observed, peroxisome, fibrosis, shr, rat, activation, agonists, figure, μmoll, treated, significantly, improved,
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gov/cder/drug/infosheets/hcp/rosiglitazone200707hcp gov/cder/drug/infosheets/hcp/pioglitazonehcp peroxisome proliferator-activated receptor-α ice-cold phosphate-buffered saline infra-red-dye labelled antibodies hmg-coa-reductase inhibitor simvastatin peroxisome proliferator-activated receptor polyclonal rabbit anti-phospho-enos nox/crea=nitric oxides related peroxisome proliferator-activated receptors hyp/pro=ratio hydroxyproline/proline α-adrenergic stimulus phenylephrine redox-regulated transcription factors redox-sensitive transcription factors porcine tachycardia-induced cardiomyopathy phenylephrine-induced vascular contraction β-myosin heavy chain38 ang ii-infused rats37 dahl-salt sensitive rats43 doca/unx salt-treated animals pmc beta search decreased patho-physiological alterations similar short-term effect reduced phenylephrine-induced hypertrophy angiotensin ii-infused rats pacing-induced heart failure doca/salt-ave8134 treated rats hypertension-induced organ damages oxidase/nitric oxide interactions monoclonal mouse anti-gapdh bone marrow-derived cells dil-labelled ox-ldl aortic endothelium-dependent relaxation transgenic cardiac-specific overexpression hans-ludwig schäfer contributed confluent cells pre-plated endothelin-1-induced cardiac hypertrophy dp/dtmin=lv minimal monoclonal mouse anti-enos cardiac function post-mi fluorescent labelled ox-ldl reference pparα-agonist fenofibrate phospho-enos protein content phospho-ser1177 enos protein tab doca=deoxycorticosterone-acetate doca-induced hypertensive rats parametric kruskal-wallis testing 3 mg·kg−1·d-1 mixed doca-salt sensitive rats receptor-mediated lipid uptake
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