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Title[redir]:
Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium - PMC
Description:
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a virulent pathogen that induces rapid host death. Here we observed that host survival after infection with S. Typhimurium was enhanced in the absence of type I interferon signaling, with ...
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Keywords {🔍}
macrophages, typhimurium, doi, ifnar, rip, infection, mice, wildtype, death, cells, fig, cell, type, pubmed, google, scholar, interferon, infected, necroptosis, pmc, activation, caspase, article, signaling, expression, free, bone, control, analysis, salmonella, immunoblot, immune, results, similar, bacterial, data, assessed, burden, survival, macrophage, role, evaluated, innate, intracellular, necrosis, shown, spleens, vitro, phosphorylated, marrowderived,
Topics {✒️}
tyr-val-ala-asp–aldehyde goat anti-rabbit igg-hrp rabbit anti-mouse igg-hrp turn cleaves pro-il-1β receptor-interacting kinase-3-mediated pathway transcription factor nf-κb bone marrow–derived macrophages l929-isre cell line ity/lsh/bcg locus phosphoinositide 3-kinase/mammalian target macrophage colony-stimulating factor nf-κb inhibitor iκb chemiluminescence-based detection system wild-type c57bl/6j mice pmc beta search antiapoptotic compound z-vad online methods mice recorded z-stack image lethally irradiated wild-type repopulated irradiated wild-type cytomegalovirus rip1-interacting protein neutralizing anti-ifn-α colony-forming units enzyme-linked immunosorbent assay lactate dehydrogenase–release assay typhimurium–infected wild-type macrophages specific cellular target rescue wild-type macrophages interferon α-induced apoptosis rip-dependent cell death immune system derived neutralizing anti-il-1β l929 cell line supplementary materials included tunel cell-death assay full-blown activation susceptible c57bl/6j mice programmed cell-death mechanisms typhimurium–induced macrophage death induce caspase-1-dependent death tumor-necrosis factor vaccinia virus expressing bone marrow cells naive wild-type mice neutralizing anti-tnf antibody isre-l929 cells infected wild-type macrophages wild-type hosts resulted luciferase assay system typhimurium–induced cell death
Questions {❓}
- Salmonella and apoptosis: to live or let die?
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