
NCBI . NLM . NIH . GOV {
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Title[redir]:
Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor beta signaling - PMC
Description:
Missense mutations in the p53 tumor suppressor inactivate its anti-proliferative properties but can also promote metastasis through a gain-of-function activity. We show that sustained expression of mutant p53 is required to maintain the ...
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Keywords {🔍}
mutant, pdgfrb, cells, doi, cancer, figure, cell, expression, pancreatic, kpc, invasion, pubmed, google, scholar, tumor, mice, metastasis, data, levels, human, metastatic, patients, expressing, lung, pmc, pdac, tumors, activity, effects, imatinib, article, panel, shown, free, kpflc, invasive, significantly, figures, pdf, disease, survival, potential, lines, presented, colorectal, function, treatment, depletion, genes, mutations,
Topics {✒️}
figure s2 nihms569074-supplement-figure_s2 figure s3 nihms569074-supplement-figure_s3 figure s4 nihms569074-supplement-figure_s4 figure s5 nihms569074-supplement-figure_s5 figure s6 nihms569074-supplement-figure_s6 figure s1 nihms569074-supplement-figure_s1 overcomes growth arrest/senescence pmc beta search poorer disease-free survival enhances trail-induced apoptosis mir-130b-zeb1 axis poor disease-free outcome poor disease-free survival 50 ng/ml pdgf-bb poor metastasis-free survival wild-type p53 possesses tumor-derived mutant forms gfp-positive signals coincided receptor tyrosine kinase serum-starved 3t3 cells small molecule inhibitor c-myc represses transcription lox-stop-lox krasg12d mono-allelic p53 mutations tumor cell-specific expression bcr/abl-induced leukemia tumor cell-secreted pdgf pdgfrb high-expressing tumors kaplan-meier survival curves empower tgfbeta-induced metastasis localized rho-dia1 function nf-yb subunit interacts disease free-survival receptor tyrosine kinases ctrl-expressing kpc cells gfp-positive kpc+sh pdgfrb-promoter-luciferase construct exert dominant-negative effects mediates pdgf-regulated proliferation anti-nf-yb antibody supplementary materials included sequence read archive dsred-positive kpc+sh pancreatic cancer harboring pancreatic ductal adenocarcinoma mutant p53-induced upregulation cells expressing shrnas wild-type p53 wild type p53 tetrameric transcription factor
Questions {❓}
- Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function?
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