
NCBI . NLM . NIH . GOV {
}
Title[redir]:
MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters - PMC
Description:
Mixed-lineage leukemia (MLL) maintains the expression of cellular memory genes during development, while leukemic MLL fusion proteins aberrantly maintain expression of hematopoietic stem cell program genes such as HOXA9 to cause leukemia. However, ...
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Keywords {🔍}
mll, domain, doi, figure, hkme, cells, proteins, genes, mutants, cxxc, fusion, pwwp, pubmed, google, scholar, hoxa, pce, target, gene, cpgs, ledgf, pmc, expression, nonmethylated, cell, supplementary, article, complex, free, histone, nucleosomes, protein, chromatin, transformation, ability, mllaf, domains, active, leukemia, nucleosome, fraction, activation, myeloid, assay, mutant, antibody, buffer, analyzed, transcriptional, binding,
Topics {✒️}
phenol/chloroform/iso-amyl alcohol extraction ell/p-tefb elongation complex bcl2/e2a-hlf-immortalized cells high-affinity menin-binding motif mll-enl-dependent gene activation nonmethyl-cpg-binding cxxc domain bcl2-ires-e2a-hlf flag-tagged histone h4 c-kit-positive cells primer pair 5′-agaattcgatatcggaaacatgactcgcgatttcaaacc-3′/5′-tcacgtgttcgcgatgcgacgggctttcgtggaggag-3′ custom-made primer sets mll fusion-dependent leukemogenesis mll-fusion complex targets proto-oncoprotein mll binds joint usage/research center mll-dependent gene activation e2a-hlf requires coexpression cpg binding-deficient mutants pmc beta search physiologic mll-dependent transcription transcriptional elongation-coupled manner hsc/immature progenitor compartments mll-af6 complex localizes mll-enl-dependent leukemogenesis promotes dna-end resection mammalian trithorax-group gene anti-c-kit antibody chromatin context-dependent mechanism anti-histone-h3 antibody vigorous colony-forming activity p-tefb facilitates oncogenic strip chromatin-binding proteins mll-enl-dependent transformation rich sequence-binding protein-1 pmscv-neo mll-enl data-dependent acquisition mode pfr-luc reporter plasmid mll-af6 target genes mll-af6-occupied loci hiv genome/integrase complex c-terminal flanking region accession numbers dra000555 c-terminal flanking sequence methylated cpg-specific binding moz histone acetyltransferase grunwald/giemsa staining method cellular memory maintenance remove chromatin-unbound materials cellular memory genes subsequent ms/ms scans
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