
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Analysis of microRNA-target interactions across diverse cancer types - PMC
Description:
Little is known about the extent to which individual microRNAs (miRNAs) regulate common processes of tumor biology across diverse cancer types. Using molecular profiles of >3,000 tumors from 11 human cancer types in The Cancer Genome Atlas, we ...
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Keywords {🔍}
cancer, expression, doi, types, target, mirna, mirnas, data, dna, mrna, mirb, pubmed, google, scholar, pmc, interactions, article, free, fig, tumor, family, samples, mirnamrna, association, network, nrep, tumors, mrnas, relationships, sets, rec, gene, cell, methylation, analysis, tdg, mirnatarget, tet, pancancer, predicted, type, tcga, pathway, score, negative, individual, genes, associations, strong, tgfβ,
Topics {✒️}
gov/tcgafiles/ftp_auth/distro_ftpusers/anonymous/tumor/ microrna-21-induced pre-b-cell lymphoma high-confidence pan-cancer network double-negative feedback loop copy-number amplification level recurring mirna-mrna relationships microrna-mediated regulatory programs recurring mirna-target interactions zeb/mir-200 feedback loop dna copy-number alterations mi rna-target relationships attenuate tgf-β signaling switch tgf-β signaling candidate mirna-target relationships rna-seq data sets pmc beta search pairwise mirna-mrna relationships dna copy-number aberrations focal mir-106b amplification candidate mirna-target interactions wilcoxon rank-sum test tgf-β signaling pathway inferred pan-cancer network evaluate mirna-mrna associations infer mirna-target interactions mirna-mrna expression covariation predict mirna-target interactions rank-based approach ensures individual mirna-target relationships mir-106b showed moderate conservation-based target interaction neck squamous-cell carcinoma gene-level-summarized pan-cancer network included predicted mirna-target interactions functional mirna-target interactions post-transcriptional regulatory interaction rank-based statistical score mirna-mrna expression association miranda-mirsvr scores aggregated high-confidence list dna-demethylation factors tet1 lung squamous-cell carcinoma pan-cancer network defined extracted mirna-mrna pairs recurrent target relationships microrna data resources laser capture microdissection genes encoding components mirna-mrna association independent
Questions {❓}
- The ZEB/miR-200 feedback loop—a motor of cellular plasticity in development and cancer?
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