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Title[redir]:
Maternal choline modifies fetal liver copper, gene expression, DNA methylation, and neonatal growth in the tx-j mouse model of Wilson disease - PMC
Description:
Maternal diet can affect fetal gene expression through epigenetic mechanisms. Wilson disease (WD), which is caused by autosomal recessive mutations in ATP7B encoding a biliary copper transporter, is characterized by excessive hepatic copper ...
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Keywords {🔍}
txj, doi, choline, mice, methylation, dna, fetal, pubmed, google, scholar, liver, levels, gene, supplementation, maternal, livers, mouse, hepatic, disease, expression, genes, global, pmc, control, cyclin, metabolism, methionine, transcript, article, copper, free, model, diet, groups, dams, cell, methyl, study, table, group, similar, untreated, dietary, pups, concentrations, increased, promoter, cpg, lipid, effects,
Topics {✒️}
s-adenosylhomocysteine hydrolase ppar α s-adenosylhomocysteine transferase intracellular s-adenosylhomocysteine methionine adenosyltransferase repeat element methylation uk/tools/seqstats/emboss_newcpgreport/ s-adenosylhomocysteine n-fold difference relative pmc beta search hepatic s-adenosylmethionine long-evans cinnamon rats dna methyltransferase abnormal transmethylation/transsulfuration metabolism sah hydrolase li-cor odyssey imager glucose-regulated protein 78 supplementary materials included gene-specific dna methylation metabolite s-adenosylmethionine background strain c3heb/fej long-lived epigenetic interactions cpg-rich gene promoters gene body-specific methylation secondary antibody conjugated detect binding fe 35 mg/kg california davis center expected low levels genotype/treatment group represents excessive hepatic copper agarose gel electrophoresis low cu concentrations liver sah levels global epigenomic reconfiguration methods animal model iron concentrations s-adenosylmethionine primary antibody advanced liver disease hepatic copper toxicosis convincing phenotype-genotype correlation pyromark pcr kit license information pmcid total dna signal biliary copper transporter publisher site pdf hepatic cu accumulation mat dnmt
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