
NCBI . NLM . NIH . GOV {
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Title[redir]:
Reduced B Lymphoid Kinase (Blk) Expression Enhances Proinflammatory Cytokine Production and Induces Nephrosis in C57BL/6-lpr/lpr Mice - PMC
Description:
BLK, which encodes B lymphoid kinase, was recently identified in genome wide association studies as a susceptibility gene for systemic lupus erythematosus (SLE), and risk alleles mapping to the BLK locus result in reduced gene expression. To ...
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Keywords {🔍}
cells, mice, blk, blklpr, blpr, expression, pubmed, doi, google, scholar, monthold, cell, levels, figure, pmc, numbers, article, development, free, disease, data, lupus, serum, plots, production, systemic, showing, immunol, percentages, sle, mouse, versus, autoimmune, susceptibility, gene, tnfα, subsets, dot, represent, erythematosus, total, proinflammatory, proteinuria, ila, shown, function, comparison, role, usa, gated,
Topics {✒️}
short-term pma/ionomycin-stimulated splenocytes short-term pma/ionomycin-stimulation short-term pma/ionomycin stimulation quantitative rt-pcr analysis fitc-donkey anti-rabbit igg effective b-cell helpers vh3h9 site directed-transgenic post-gwas functional characterization representative histograms showing c57bl/6-lpr/lpr mice elizabeth bcr-coupled signaling pathway bdca2/fcεr1γ complex signals pmc beta search immobilized anti-cd3 antibody bleomycin-induced experimental scleroderma genome-wide association analysis anti-cd16/cd32 antibody methods ethics statement genome-wide association scan pas-positive hyaline deposits genome-wide association study enhanced icos-icosl signaling rt2 profiler array blk-deficiency differentially affect anti-tnfα monoclonal antibody elevated il-17a production antibody class-switch soluble anti-cd28 antibody recent reports showing license information pmcid nf- κb family serum anti-nuclear antibodies mrl/mpj-faslpr/lpr/ b-cell development augmented icos-icosl interactions representative light micrographs biomed biotech doi publisher site pdf cd4+ tcrβ+ cd3+ c57bl/6-lpr/lpr mice short-lived plasma cells nf-κb activation plots represent percentages anti-dsdna igg antibodies adjacent graph compares il-21 receptor signaling supplementary materials included plots represent percentage icos receptor instructs demonstrated enhanced production
Questions {❓}
- Could it be a new entity within the spectrum of lupus nephritis?
- Rai E, Wakeland EK (2011) Genetic predisposition to autoimmunity – what have we learned?
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