NCBI . NLM . NIH . GOV {
}
We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC3935725/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC3935725/. The analysis below is for the second page.
Title[redir]:
ER stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway - PMC
Description:
The accumulation of improperly folded proteins within the endoplasmic reticulum (ER) generates perturbations known as ER stress that engage the unfolded protein response (UPR). ER stress is involved in many inflammatory pathologies that are also ...
Title[redir]:
ER stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway - PMC
Description:
The accumulation of improperly folded proteins within the endoplasmic reticulum (ER) generates perturbations known as ER stress that engage the unfolded protein response (UPR). ER stress is involved in many inflammatory pathologies that are also ...
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Keywords {🔍}
caspase, stress, ilβ, doi, response, lps, tlr, production, stimulation, fig, bmdm, pmc, inflammasome, activation, cells, casp, pubmed, google, scholar, ripk, proilβ, article, protein, cell, signaling, supplemental, free, upr, found, mice, treated, maturation, data, mature, pathway, chop, inflammation, role, induction, nlm, proteins, asc, agonists, drugs, secretion, death, macrophages, interestingly, xbp, trif,
Topics {✒️}
immature cytokines pro-il-1β lps-induced il-1β production proinflammatory cytokine interleukin-1β proteolytically activate pro-il-1β map kinase c-jun aalac-accredited animal facility mediates noncanonical il-1beta er stress-induced inflammation cleave pro-il-1β pro-il-1β levels pro-il-1β production th17-promoting adjuvant activity induce il-1β production induce pro-il-1β mature il-1β production pmc beta search adapter-inducing interferon-β il-1-driven tissue pathology synergistic ifn-beta induction er stress-inducing drugs necrotic-type cell death il-1β ready-set produce mature il-1β mature il-1β secretion pro-il-1β occurs il-1β production require enhanced anti-viral responses pmc copyright notice modulates immune responses produce proinflammatory cytokines il-1β production pro-il-1β complexly regulated cytokine mature il-1β myd88-dependent signaling downstream box-binding protein 1 il-1β elisa noncanonical inflammasome activation pro-caspase-8 levels protein kinase rna rip3-independent manner il-1β concentration il-1β maturation partially required caspase-1/caspase-11 induce er stress cytokines interferon-β il-1β secretion license information pmcid supplementary materials included noncanonical caspase-8 inflammasome
Questions {❓}
- ER stress-induced inflammation: does it aid or impede disease progression?
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