
NCBI . NLM . NIH . GOV {
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Title[redir]:
Cancer stem cells in colorectal cancer from pathogenesis to therapy: Controversies and perspectives - PMC
Description:
Colorectal cancer remains one of the most common and lethal malignancies worldwide despite the use of various therapeutic strategies. A better understanding of the mechanisms responsible for tumor initiation and progression is essential for the ...
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Keywords {🔍}
doi, cells, cancer, pubmed, google, scholar, cell, crc, stem, expression, tumor, colon, colorectal, human, pmc, free, article, cscs, csc, marker, wnt, tumors, patients, potential, signaling, survival, normal, role, figure, molecule, pathway, development, model, tumorigenesis, epcam, specific, prognostic, growth, lgr, protein, activation, expressed, therapy, markers, showed, extracellular, metastatic, target, adhesion, res,
Topics {✒️}
beta-catenin/tcf-4 complex imposes inhibiting α-catenin-dependent transcription inhibiting pp2a/akt/mtor pathways ras-raf-mek-erk pathway human colon-cancer-initiating cells cell-adhesion free condition pci-based anti-csc strategy sessile serrated adenoma-polyp-lesions pmc beta search bispecific epcam/cd133-targeted toxin generate transit-amplifying cells amp-activated protein kinase long-lived stem cells increasing α-tubulin acetylation therapy-induced acute recruitment easier antibody-based techniques transcriptional regulators β-catenin cytosolic β-catenin levels conventional clinic-pathological factors pp2ac/akt/mtor pathway beta-catenin-tcf complex ras-raf axis underlie wnt-beta-catenin signaling β-catenin/tcf-4 signaling intestinal wnt/tcf signature g-protein-coupled receptors chemo-preventive agent proved surface phenotype epcamhigh/cd44+/cd166+ c-terminal cytoplasmic tail anti-dll4 inhibits growth fluorescence-activated cell sorting cancer-initiating cells derived single-chain variable fragment tumor suppressor mir-34a cancer-initiating cells isolated sodium butyrate-induced differentiation report-based screening approaches β-catenin mutation inhibits wnt/wingless signaling pathway transcriptional regulator β-catenin wnt/β-catenin pathway future anti-cancer protocols platelet-derived growth factors specific csc-surface markers clinic-pathological variables dna inducing c-myc small molecule-mediated disruption csc-specific imaging techniques stem/progenitor cell marker[27] src kinase-dependent manner
Questions {❓}
- CD6-ligand interactions: a paradigm for SRCR domain function?
- Divergent expression of CD133 in different studies: the need for a consensus panel?
- Targeting Wnt signaling: can we safely eradicate cancer stem cells?
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- How much money does https://doi.org/10.1371/journal.pone.0059563 generate?
- Learn about the earnings of https://scholar.google.com/scholar_lookup?journal=PLoS%20One&title=CD24%20induces%20expression%20of%20the%20oncomir%20miR-21%20via%20Src,%20and%20CD24%20and%20Src%20are%20both%20post-transcriptionally%20downregulated%20by%20the%20tumor%20suppressor%20miR-34a&author=S%20Muppala&author=G%20Mudduluru&author=JH%20Leupold&author=D%20Buergy&author=JP%20Sleeman&volume=8&publication_year=2013&pages=e59563&pmid=23533633&doi=10.1371/journal.pone.0059563&
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- How much profit does https://doi.org/10.1016/s0092-8674(02)00971-6 make?
- How much income does https://scholar.google.com/scholar_lookup?journal=Cell&title=Integrins:%20bidirectional,%20allosteric%20signaling%20machines&author=RO%20Hynes&volume=110&publication_year=2002&pages=673-687&pmid=12297042&doi=10.1016/s0092-8674(02)00971-6& have?
- How much money does https://doi.org/10.1038/bjc.1992.328 make?
- How much revenue does https://scholar.google.com/scholar_lookup?journal=Br%20J%20Cancer&title=Morphoregulatory%20activities%20of%20E-cadherin%20and%20beta-1%20integrins%20in%20colorectal%20tumour%20cells&author=M%20Pignatelli&author=D%20Liu&author=MM%20Nasim&author=GW%20Stamp&author=S%20Hirano&volume=66&publication_year=1992&pages=629-634&pmid=1384639&doi=10.1038/bjc.1992.328& bring in?
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- How much does https://scholar.google.com/scholar_lookup?journal=J%20Surg%20Res&title=Enhancement%20of%20metastatic%20activity%20of%20colon%20cancer%20as%20influenced%20by%20expression%20of%20cell%20surface%20antigens&author=K%20Okazaki&author=Y%20Nakayama&author=K%20Shibao&author=K%20Hirata&author=N%20Nagata&volume=78&publication_year=1998&pages=78-84&pmid=9733622&doi=10.1006/jsre.1998.5298& pull in?
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- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=J%20Cancer&title=A%20Pilot%20Study%20Assessing%20the%20Potential%20Role%20of%20non-CD133%20Colorectal%20Cancer%20Stem%20Cells%20as%20Biomarkers&author=RC%20Langan&author=JE%20Mullinax&author=S%20Ray&author=MT%20Raiji&author=N%20Schaub&volume=3&publication_year=2012&pages=231-240&pmid=22670157&doi=10.7150/jca.4542&?
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- https://scholar.google.com/scholar_lookup?journal=Cell&title=The%20beta-catenin/TCF-4%20complex%20imposes%20a%20crypt%20progenitor%20phenotype%20on%20colorectal%20cancer%20cells&author=Wetering%20M%20van%20de&author=E%20Sancho&author=C%20Verweij&author=W%20de%20Lau&author=I%20Oving&volume=111&publication_year=2002&pages=241-250&pmid=12408868&doi=10.1016/s0092-8674(02)01014-0&'s total income per month
- Learn about the earnings of https://doi.org/10.1186/1477-7819-10-244
- What's https://scholar.google.com/scholar_lookup?journal=World%20J%20Surg%20Oncol&title=Lgr5%20is%20a%20potential%20marker%20of%20colorectal%20carcinoma%20stem%20cells%20that%20correlates%20with%20patient%20survival&author=XS%20Wu&author=HQ%20Xi&author=L%20Chen&volume=10&publication_year=2012&pages=244&pmid=23153436&doi=10.1186/1477-7819-10-244&'s gross income?
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- How much revenue does https://scholar.google.com/scholar_lookup?journal=Immunol%20Today&title=CD6-ligand%20interactions:%20a%20paradigm%20for%20SRCR%20domain%20function?&author=A%20Aruffo&author=MA%20Bowen&author=DD%20Patel&author=BF%20Haynes&author=GC%20Starling&volume=18&publication_year=1997&pages=498-504&pmid=9357143&doi=10.1016/s0167-5699(97)01130-4& bring in?
- Revenue of https://scholar.google.com/scholar_lookup?journal=Cancer%20Genomics%20Proteomics&title=ALCAM/CD166:%20cancer-related%20issues&author=UH%20Weidle&author=D%20Eggle&author=S%20Klostermann&author=GW%20Swart&volume=7&publication_year=2010&pages=231-243&pmid=20952758&
- What is the monthly revenue of https://doi.org/10.1053/j.gastro.2010.08.053?
- What is the monthly revenue of https://scholar.google.com/scholar_lookup?journal=Gastroenterology&title=Characterization%20of%20the%20intestinal%20cancer%20stem%20cell%20marker%20CD166%20in%20the%20human%20and%20mouse%20gastrointestinal%20tract&author=TG%20Levin&author=AE%20Powell&author=PS%20Davies&author=AD%20Silk&author=AD%20Dismuke&volume=139&publication_year=2010&pages=2072-2082.e5&pmid=20826154&doi=10.1053/j.gastro.2010.08.053&?
- Income figures for https://doi.org/10.1136/jcp.2004.016238
- How much does https://scholar.google.com/scholar_lookup?journal=J%20Clin%20Pathol&title=ALCAM/CD166%20is%20overexpressed%20in%20colorectal%20carcinoma%20and%20correlates%20with%20shortened%20patient%20survival&author=W%20Weichert&author=T%20Kn%C3%B6sel&author=J%20Bellach&author=M%20Dietel&author=G%20Kristiansen&volume=57&publication_year=2004&pages=1160-1164&pmid=15509676&doi=10.1136/jcp.2004.016238& generate monthly?
- How profitable is https://doi.org/10.1080/07357900902744502?
- What's the revenue for https://scholar.google.com/scholar_lookup?journal=Cancer%20Invest&title=Prognostic%20significance%20of%20the%20cancer%20stem%20cell%20markers%20CD133,%20CD44,%20and%20CD166%20in%20colorectal%20cancer&author=D%20Horst&author=L%20Kriegl&author=J%20Engel&author=T%20Kirchner&author=A%20Jung&volume=27&publication_year=2009&pages=844-850&pmid=19626493&doi=10.1080/07357900902744502&?
- What are the earnings of https://doi.org/10.1016/j.jss.2012.02.013?
- How profitable is https://scholar.google.com/scholar_lookup?journal=J%20Surg%20Res&title=Activated%20leukocyte%20cell%20adhesion%20molecule%20(CD166)--its%20prognostic%20power%20for%20colorectal%20cancer%20patients&author=M%20Tachezy&author=H%20Zander&author=F%20Gebauer&author=A%20Marx&author=JT%20Kaifi&volume=177&publication_year=2012&pages=e15-e20&pmid=22482754&doi=10.1016/j.jss.2012.02.013&?
- What are the earnings of https://doi.org/10.1172/JCI41004?
- What's the monthly money flow for https://scholar.google.com/scholar_lookup?journal=J%20Clin%20Invest&title=The%20therapeutic%20promise%20of%20the%20cancer%20stem%20cell%20concept&author=NY%20Frank&author=T%20Schatton&author=MH%20Frank&volume=120&publication_year=2010&pages=41-50&pmid=20051635&doi=10.1172/JCI41004&?
- What are the earnings of https://doi.org/10.1016/j.stem.2007.08.001?
- https://scholar.google.com/scholar_lookup?journal=Cell%20Stem%20Cell&title=Colon%20cancer%20stem%20cells%20dictate%20tumor%20growth%20and%20resist%20cell%20death%20by%20production%20of%20interleukin-4&author=M%20Todaro&author=MP%20Alea&author=Stefano%20AB%20Di&author=P%20Cammareri&author=L%20Vermeulen&volume=1&publication_year=2007&pages=389-402&pmid=18371377&doi=10.1016/j.stem.2007.08.001&'s financial summary
- How much profit does https://doi.org/10.1158/0008-5472.CAN-08-2023 generate?
- Earnings of https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Chemoresistant%20colorectal%20cancer%20cells,%20the%20cancer%20stem%20cell%20phenotype,%20and%20increased%20sensitivity%20to%20insulin-like%20growth%20factor-I%20receptor%20inhibition&author=NA%20Dallas&author=L%20Xia&author=F%20Fan&author=MJ%20Gray&author=P%20Gaur&volume=69&publication_year=2009&pages=1951-1957&pmid=19244128&doi=10.1158/0008-5472.CAN-08-2023&
- How much cash flow does https://doi.org/10.1158/0008-5472.CAN-12-2221 have monthly?
- What's the income generated by https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Specific%20elimination%20of%20CD133+%20tumor%20cells%20with%20targeted%20oncolytic%20measles%20virus&author=P%20Bach&author=T%20Abel&author=C%20Hoffmann&author=Z%20Gal&author=G%20Braun&volume=73&publication_year=2013&pages=865-874&pmid=23293278&doi=10.1158/0008-5472.CAN-12-2221& each month?
- How profitable is https://doi.org/10.1016/j.jconrel.2013.03.023?
- See how much https://scholar.google.com/scholar_lookup?journal=J%20Control%20Release&title=Photochemical%20internalization%20(PCI)%20of%20immunotoxins%20targeting%20CD133%20is%20specific%20and%20highly%20potent%20at%20femtomolar%20levels%20in%20cells%20with%20cancer%20stem%20cell%20properties&author=M%20Bostad&author=K%20Berg&author=A%20H%C3%B8gset&author=E%20Skarpen&author=H%20Stenmark&volume=168&publication_year=2013&pages=317-326&pmid=23567040&doi=10.1016/j.jconrel.2013.03.023& makes per month
- What's https://doi.org/10.1016/j.canlet.2013.04.031's gross income?
- How much revenue does https://scholar.google.com/scholar_lookup?journal=Cancer%20Lett&title=Low%20glucose%20promotes%20CD133mAb-elicited%20cell%20death%20via%20inhibition%20of%20autophagy%20in%20hepatocarcinoma%20cells&author=H%20Chen&author=Z%20Luo&author=W%20Sun&author=C%20Zhang&author=H%20Sun&volume=336&publication_year=2013&pages=204-212&pmid=23652197&doi=10.1016/j.canlet.2013.04.031& produce monthly?
- https://doi.org/10.1016/j.jconrel.2013.07.014 income
- Income figures for https://scholar.google.com/scholar_lookup?journal=J%20Control%20Release&title=CD133-targeted%20paclitaxel%20delivery%20inhibits%20local%20tumor%20recurrence%20in%20a%20mouse%20model%20of%20breast%20cancer&author=SK%20Swaminathan&author=E%20Roger&author=U%20Toti&author=L%20Niu&author=JR%20Ohlfest&volume=171&publication_year=2013&pages=280-287&pmid=23871962&doi=10.1016/j.jconrel.2013.07.014&
- Learn how profitable https://doi.org/10.1016/s0140-6736(94)92398-1 is on a monthly basis
- Get to know what's the income of https://scholar.google.com/scholar_lookup?journal=Lancet&title=Randomised%20trial%20of%20monoclonal%20antibody%20for%20adjuvant%20therapy%20of%20resected%20Dukes%E2%80%99%20C%20colorectal%20carcinoma.%20German%20Cancer%20Aid%2017-1A%20Study%20Group&author=G%20Riethm%C3%BCller&author=E%20Schneider-G%C3%A4dicke&author=G%20Schlimok&author=W%20Schmiegel&author=R%20Raab&volume=343&publication_year=1994&pages=1177-1183&pmid=7909866&doi=10.1016/s0140-6736(94)92398-1&
- https://doi.org/10.1016/S0140-6736(02)09836-7's financial summary
- How much profit does https://scholar.google.com/scholar_lookup?journal=Lancet&title=Edrecolomab%20alone%20or%20in%20combination%20with%20fluorouracil%20and%20folinic%20acid%20in%20the%20adjuvant%20treatment%20of%20stage%20III%20colon%20cancer:%20a%20randomised%20study&author=CJ%20Punt&author=A%20Nagy&author=JY%20Douillard&author=A%20Figer&author=T%20Skovsgaard&volume=360&publication_year=2002&pages=671-677&pmid=12241873&doi=10.1016/S0140-6736(02)09836-7& make?
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- https://doi.org/10.1039/c2nr32145a income
- Earnings of https://scholar.google.com/scholar_lookup?journal=Nanoscale&title=Hyaluronic%20acid%20modified%20mesoporous%20silica%20nanoparticles%20for%20targeted%20drug%20delivery%20to%20CD44-overexpressing%20cancer%20cells&author=M%20Yu&author=S%20Jambhrunkar&author=P%20Thorn&author=J%20Chen&author=W%20Gu&volume=5&publication_year=2013&pages=178-183&pmid=23076766&doi=10.1039/c2nr32145a&
- How much money does https://doi.org/10.1158/0008-5472.CAN-07-6463 make?
- See how much https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Targeting%20CD24%20for%20treatment%20of%20colorectal%20and%20pancreatic%20cancer%20by%20monoclonal%20antibodies%20or%20small%20interfering%20RNA&author=E%20Sagiv&author=A%20Starr&author=U%20Rozovski&author=R%20Khosravi&author=P%20Altevogt&volume=68&publication_year=2008&pages=2803-2812&pmid=18413748&doi=10.1158/0008-5472.CAN-07-6463& makes per month
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- What's https://scholar.google.com/scholar_lookup?journal=Nature&title=Functional%20interaction%20of%20beta-catenin%20with%20the%20transcription%20factor%20LEF-1&author=J%20Behrens&author=JP%20von%20Kries&author=M%20K%C3%BChl&author=L%20Bruhn&author=D%20Wedlich&volume=382&publication_year=1996&pages=638-642&pmid=8757136&doi=10.1038/382638a0&'s gross income?
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