
NCBI . NLM . NIH . GOV {
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Title[redir]:
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease - PMC
Description:
Transforming growth factor-β1 (TGF-β1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-β1 gene by homologous recombination in murine embryonic stem ...
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Keywords {🔍}
tgfβ, doi, animals, google, scholar, mutant, pubmed, homozygous, cells, cell, inflammatory, inflammation, pmc, control, mice, fig, allele, targeting, mouse, gene, analysis, observed, article, heterozygous, immun, wildtype, free, normal, probe, liver, pmd, growth, disrupted, expression, development, embryonic, days, necrosis, infiltration, pcr, exhibited, phenotype, immune, including, detected, genomic, total, neutrophils, death, tissues,
Topics {✒️}
involve interferon-γ-induced expression wild-type tgf-β1 mrna tgf-β1-deficient animals occurs transforming growth factor-β1 anti-inflammatory drug therapy parent-matched homozygous wild-type modified tgf-β1 allele altered tgf-β1 allele tgf-β1 genomic fragment genomic tgf-β1 sequence c3h/hen × c57bl/6j tgf-β1 deficiency resulted tgf-β1-deficient mice tgf-β1 deficient mice murine tgf-β1 gene disrupted tgf-β1 gene involving epithelial-mesenchymal interactions disrupted tgf-β1 allele ethidium bromide-stained gel pmc beta search targeted tgf-β1 gene tgf-β1 inhibits adhesiveness tgf-β1 gene targeting targeted tgf-β1 allele tgf-β1-deficient cells tgf-β1 include regulation macrophage inflammatory protein-1α precursor iga-secreting cells precursor pro-region intact multiple tgf-β isoforms tgf-β1 locus involve tgf-β1 tgf-β1 gene homozygous mutant class including interferon-γ morphogenetic growth factor murine embryonic stem interferon-γ production orally induced suppression individual pcr-positive clones neor gene lacking tgf-β1 deficiency d3 embryonic stem collagen-induced arthritis growth factor production25 gene1-3 tgf-β1 termed tgf-β1 tgf-β1 immunoreactivity tgf-β1 administration wild-type allele
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