
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Repair of Strand Breaks by Homologous Recombination - PMC
Description:
Breaks in both strands of DNA are caused by environmental agents (e.g., ionizing radiation) or errors in normal cellular processes (e.g., replication). Homologous recombination is one major pathway to repair such breaks.
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Keywords {🔍}
google, scholar, pubmed, doi, dna, repair, pmc, free, article, cell, cells, recombination, rad, dsb, yeast, breaks, doublestrand, mammalian, homologous, dsbs, biol, proteins, end, resection, chromosome, jasin, mol, gene, protein, brca, ends, nhej, strand, genome, break, damage, pathway, plasmid, increased, chromosomal, complex, studies, role, mobility, nature, meiotic, chen, site, rothstein, endonuclease,
Topics {✒️}
double-strand-break-repair defect rap80/abraxas/brca1/brcc36 complex p-element-induced gap repair suppressing error-prone repair double-strand-break repair model unique double-strand break dna double-strand break temperature-sensitive sporulation-deficient mutants genomic double-strand breaks ends involves mre11/rad50/xrs2 sumo-dependent ubiquitin ligase intron-encoded omega transposase dna double-strand breaks programmable dna-nicking enzymes rag-induced dna breaks single double-strand breaks foreign β-globin gene dynamic giga-dalton assemblies nonconservative single-strand annealing lac operator/repressor recognition pmc beta search single-stranded dna generated error-prone nhej ubiquitin-dependent signaling cascade designed zinc-finger nucleases orr-weaver tl hrad50-hmre11-p95 complex exo1-blm-rpa-mrn constitute brca-mutated breast cancers cross-strand exchange structure double-strand gap repair nonhomologous end-joining [nhej] zfn-based nicking enzyme tal-type iii effectors intron-encoded endonuclease expressed ho-induced chromosomal breaks alternative end-joining pathway double-strand break introduce site-specific dsbs termed microhomology-mediated nhej reca-ssdna/dsdna structures ionizing radiation-induced assembly γ-irradiation-induced breaks create site-specific dsbs 18-base-pair recognition site site-specific endonuclease essential site-specific breaks introduced mammalian mre11/rad50/nbs1 single-strand annealing [ssa] combined helicase/nuclease activities
Questions {❓}
- How damaged is the biologically active subpopulation of transfected DNA?
- How does the cell “know” what to do when confronted with broken DNA?
- What are all of the proteins doing in the gigadalton complexes that form around broken DNA?
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